MED31 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051123Biological processRNA polymerase II preinitiation complex assembly
GO_0060173Biological processlimb development
GO_0016567Biological processprotein ubiquitination
GO_0060261Biological processpositive regulation of transcription initiation by RNA polymerase II
GO_0048147Biological processnegative regulation of fibroblast proliferation
GO_0032968Biological processpositive regulation of transcription elongation by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000151Cellular componentubiquitin ligase complex
GO_0016592Cellular componentmediator complex
GO_0005654Cellular componentnucleoplasm
GO_0070847Cellular componentcore mediator complex
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding
GO_0003712Molecular functiontranscription coregulator activity

IV. Literature review

[source]
Gene nameMED31
Protein nameMediator of RNA polymerase II transcription subunit 31 (Mediator complex subunit 31) (Mediator complex subunit SOH1) (hSOH1)
Mediator of RNA polymerase II transcription subunit 31
SynonymsCGI-125
SOH1
DescriptionFUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. .

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. .

AccessionsENST00000575197.1
I3L2J1
Q9Y3C7
I3L0P8
ENST00000574128.1
ENST00000225728.8