MED18 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MED18 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MED18 at tissue level.

III. Associated gene sets

GO_0051123Biological processRNA polymerase II preinitiation complex assembly
GO_0016567Biological processprotein ubiquitination
GO_0060261Biological processpositive regulation of transcription initiation by RNA polymerase II
GO_0032968Biological processpositive regulation of transcription elongation by RNA polymerase II
GO_0006369Biological processtermination of RNA polymerase II transcription
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000151Cellular componentubiquitin ligase complex
GO_0016592Cellular componentmediator complex
GO_0005654Cellular componentnucleoplasm
GO_0070847Cellular componentcore mediator complex
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding
GO_0003712Molecular functiontranscription coregulator activity

IV. Literature review

[source]
Gene nameMED18
Protein nameMediator of RNA polymerase II transcription subunit 18 (Mediator complex subunit 18)
Mediator of RNA polymerase II transcription subunit 18 (Mediator complex subunit 18) (p28b)
Synonyms
DescriptionFUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. .

AccessionsB4DJL3
ENST00000398997.2
ENST00000373842.9
ENST00000645794.2
ENST00000647352.1
Q9BUE0