MED12L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016592Cellular componentmediator complex
GO_0008134Molecular functiontranscription factor binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding
GO_0008013Molecular functionbeta-catenin binding

IV. Literature review

[source]
Gene nameMED12L
Protein nameMED12L protein
Mediator of RNA polymerase II transcription subunit 12-like protein (Mediator complex subunit 12-like protein) (Thyroid hormone receptor-associated-like protein) (Trinucleotide repeat-containing gene 11 protein-like)
Mediator complex subunit 12L
SynonymsPRO0314
TRALP
TRALPUSH
TNRC11L
KIAA1635
DescriptionFUNCTION: May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). .

AccessionsENST00000688234.1
ENST00000422248.6 [Q86YW9-2]
H7C4I9
ENST00000309237.8 [Q86YW9-3]
Q86YW9
ENST00000480026.1
ENST00000273432.8
B7ZMI1
ENST00000474524.5 [Q86YW9-1]
F8WAE6
A0A8I5KW22
ENST00000686666.1
ENST00000687756.1
A0A8I5KY35
A0A8I5KX78