MED11 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MED11 at tissue level.

III. Associated gene sets

GO_0051123Biological processRNA polymerase II preinitiation complex assembly
GO_0016567Biological processprotein ubiquitination
GO_0060261Biological processpositive regulation of transcription initiation by RNA polymerase II
GO_0032968Biological processpositive regulation of transcription elongation by RNA polymerase II
GO_0000151Cellular componentubiquitin ligase complex
GO_0016592Cellular componentmediator complex
GO_0005654Cellular componentnucleoplasm
GO_0070847Cellular componentcore mediator complex
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding
GO_0003712Molecular functiontranscription coregulator activity

IV. Literature review

[source]
Gene nameMED11
Protein nameMediator of RNA polymerase II transcription subunit 11 (Mediator complex subunit 11)
Mediator complex subunit 11
SynonymsHSPC296
DescriptionFUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for theee assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. .

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. .

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. .

FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. .

AccessionsI3L2Q0
A0A6I8PLG6
ENST00000575284.5
ENST00000674339.1
ENST00000573708.1
Q9P086
U4PP31
ENST00000293777.6
I3L3E8