MDN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000027Biological processribosomal large subunit assembly
GO_0000055Biological processribosomal large subunit export from nucleus
GO_0045111Cellular componentintermediate filament cytoskeleton
GO_0030687Cellular componentpreribosome, large subunit precursor
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameMDN1
Protein nameMDN1 protein
Midasin (Dynein-related AAA-ATPase MDN1) (MIDAS-containing protein)
SynonymsKIAA0301
DescriptionFUNCTION: Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits . Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex . This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (By similarity). .

AccessionsQ6PJJ1
ENST00000369393.8
Q9NU22