MCOLN2 | OmnibusX

Name	Number of supported studies	Average coverage
plasmacytoid dendritic cell	11 studies	22% ± 7%	Explore
dendritic cell	6 studies	31% ± 12%	Explore
CD8-positive, alpha-beta T cell	3 studies	17% ± 2%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of MCOLN2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	946.84	577 / 578	92%	5.09	1057 / 1155
skin	84%	153.46	1526 / 1809	95%	8.31	449 / 472
intestine	78%	802.27	751 / 966	87%	7.58	461 / 527
prostate	72%	108.21	177 / 245	86%	5.13	430 / 502
stomach	72%	145.85	260 / 359	85%	6.75	243 / 286
breast	68%	107.55	311 / 459	88%	4.44	989 / 1118
pancreas	59%	70.94	194 / 328	75%	2.82	134 / 178
adrenal gland	100%	1388.84	258 / 258	32%	2.48	73 / 230
bladder	52%	71.86	11 / 21	70%	4.70	353 / 504
thymus	53%	96.13	347 / 653	66%	2.81	401 / 605
kidney	55%	87.07	49 / 89	64%	2.18	577 / 901
uterus	38%	70.45	65 / 170	77%	3.12	352 / 459
esophagus	36%	47.18	526 / 1445	77%	3.31	140 / 183
ovary	21%	20.56	38 / 180	88%	4.08	377 / 430
lymph node	0%	0	0 / 0	100%	60.19	29 / 29
spleen	100%	1131.42	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	91%	5.38	41 / 45
peripheral blood	79%	2461.42	735 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	65%	1.97	52 / 80
adipose	55%	85.39	659 / 1204	0%	0	0 / 0
blood vessel	40%	71.77	538 / 1335	0%	0	0 / 0
brain	5%	4.52	138 / 2642	32%	1.04	224 / 705
liver	11%	9.77	24 / 226	24%	0.84	97 / 406
heart	20%	18.96	169 / 861	0%	0	0 / 0
muscle	9%	15.09	71 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_1990266	Biological process	neutrophil migration
GO_0019722	Biological process	calcium-mediated signaling
GO_0045087	Biological process	innate immune response
GO_0034755	Biological process	iron ion transmembrane transport
GO_2000343	Biological process	positive regulation of chemokine (C-X-C motif) ligand 2 production
GO_0002250	Biological process	adaptive immune response
GO_1905517	Biological process	macrophage migration
GO_0071639	Biological process	positive regulation of monocyte chemotactic protein-1 production
GO_0071642	Biological process	positive regulation of macrophage inflammatory protein 1 alpha production
GO_0015031	Biological process	protein transport
GO_0071651	Biological process	positive regulation of chemokine (C-C motif) ligand 5 production
GO_0070588	Biological process	calcium ion transmembrane transport
GO_0031902	Cellular component	late endosome membrane
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0055038	Cellular component	recycling endosome membrane
GO_0005765	Cellular component	lysosomal membrane
GO_0072345	Molecular function	NAADP-sensitive calcium-release channel activity
GO_0042802	Molecular function	identical protein binding
GO_0005381	Molecular function	iron ion transmembrane transporter activity
GO_0005262	Molecular function	calcium channel activity

Gene name	MCOLN2
Protein name	Mucolipin 2, isoform CRA_a (Mucolipin TRP cation channel 2) Mucolipin-2 (Transient receptor potential channel mucolipin 2) (TRPML2)
Synonyms	hCG_2039430
Description	FUNCTION: Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity . May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway . May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events . .
Accessions	G5EA24 ENST00000284027.5 [Q8IZK6-2] ENST00000463065.5 Q8IZK6 ENST00000370608.8 [Q8IZK6-1]

MCOLN2 report