MCM8 | OmnibusX

Name	Number of supported studies	Average coverage
liver	3 studies	18% ± 0%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	777.01	1444 / 1445	100%	6.45	183 / 183
ovary	100%	622.11	180 / 180	99%	4.91	427 / 430
uterus	100%	895.09	170 / 170	99%	6.76	455 / 459
breast	100%	743.61	459 / 459	99%	3.88	1104 / 1118
stomach	100%	682.13	358 / 359	99%	5.36	282 / 286
prostate	100%	904.23	245 / 245	98%	2.35	493 / 502
lung	99%	602.58	575 / 578	98%	4.39	1130 / 1155
bladder	100%	804.05	21 / 21	97%	4.16	489 / 504
intestine	100%	914.93	966 / 966	96%	4.27	508 / 527
skin	100%	1164.16	1807 / 1809	95%	4.63	447 / 472
pancreas	99%	458.39	325 / 328	88%	2.10	157 / 178
adrenal gland	100%	726.79	258 / 258	80%	1.84	185 / 230
thymus	100%	626.28	653 / 653	77%	1.56	466 / 605
kidney	100%	513.48	89 / 89	77%	1.64	693 / 901
brain	88%	348.80	2316 / 2642	86%	2.33	603 / 705
liver	86%	227.64	194 / 226	59%	1.57	239 / 406
lymph node	0%	0	0 / 0	100%	5.48	29 / 29
muscle	100%	954.23	803 / 803	0%	0	0 / 0
spleen	100%	864.37	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	6.63	45 / 45
adipose	100%	629.57	1203 / 1204	0%	0	0 / 0
blood vessel	100%	631.79	1333 / 1335	0%	0	0 / 0
heart	94%	521.44	812 / 861	0%	0	0 / 0
peripheral blood	72%	987.67	666 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	53%	1.03	42 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0032508	Biological process	DNA duplex unwinding
GO_0006974	Biological process	DNA damage response
GO_0006260	Biological process	DNA replication
GO_0000724	Biological process	double-strand break repair via homologous recombination
GO_0048232	Biological process	male gamete generation
GO_0050821	Biological process	protein stabilization
GO_0036298	Biological process	recombinational interstrand cross-link repair
GO_0070716	Biological process	mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication
GO_0071168	Biological process	protein localization to chromatin
GO_0007292	Biological process	female gamete generation
GO_0005654	Cellular component	nucleoplasm
GO_0097362	Cellular component	MCM8-MCM9 complex
GO_0042555	Cellular component	MCM complex
GO_0005694	Cellular component	chromosome
GO_0005634	Cellular component	nucleus
GO_0019899	Molecular function	enzyme binding
GO_0032407	Molecular function	MutSalpha complex binding
GO_0003682	Molecular function	chromatin binding
GO_0003697	Molecular function	single-stranded DNA binding
GO_0017116	Molecular function	single-stranded DNA helicase activity
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding
GO_0032408	Molecular function	MutSbeta complex binding
GO_0016887	Molecular function	ATP hydrolysis activity
GO_0032406	Molecular function	MutLbeta complex binding

Gene name	MCM8
Protein name	DNA helicase MCM8 (EC 3.6.4.12) DNA helicase MCM8 (EC 3.6.4.12) (Minichromosome maintenance 8)
Synonyms	C20orf154
Description	FUNCTION: Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) . Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity . Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs . The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression . However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC) . Probably by regulating HR, plays a key role during gametogenesis (By similarity). Stabilizes MCM9 protein . .
Accessions	ENST00000378886.6 [Q9UJA3-4] A0A0S2Z5R6 Q9UJA3 ENST00000378896.7 [Q9UJA3-1] A0A0S2Z618 ENST00000378883.5 [Q9UJA3-2] ENST00000610722.4 [Q9UJA3-1] A0A0S2Z5Q9 ENST00000265187.4 [Q9UJA3-3]

MCM8 report