MCM6 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MCM6 at tissue level.

III. Associated gene sets

GO_0000727Biological processdouble-strand break repair via break-induced replication
GO_0006268Biological processDNA unwinding involved in DNA replication
GO_0006270Biological processDNA replication initiation
GO_0006260Biological processDNA replication
GO_0030174Biological processregulation of DNA-templated DNA replication initiation
GO_1902969Biological processmitotic DNA replication
GO_0042555Cellular componentMCM complex
GO_0071162Cellular componentCMG complex
GO_0000781Cellular componentchromosome, telomeric region
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0003678Molecular functionDNA helicase activity
GO_1990518Molecular functionsingle-stranded 3'-5' DNA helicase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameMCM6
Protein nameDNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM)
DNA replication licensing factor MCM6 (EC 3.6.4.12)
Uncharacterized protein MCM6
Synonyms
DescriptionFUNCTION: Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built . The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity . .

FUNCTION: Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. .

AccessionsQ53T61
ENST00000264156.3
Q14566
Q4ZG57