MCM3AP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006406Biological processmRNA export from nucleus
GO_0015031Biological processprotein transport
GO_0016446Biological processsomatic hypermutation of immunoglobulin genes
GO_0034728Biological processnucleosome organization
GO_0016973Biological processpoly(A)+ mRNA export from nucleus
GO_0005654Cellular componentnucleoplasm
GO_0070390Cellular componenttranscription export complex 2
GO_0044615Cellular componentnuclear pore nuclear basket
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005694Cellular componentchromosome
GO_0031965Cellular componentnuclear membrane
GO_0005634Cellular componentnucleus
GO_0042393Molecular functionhistone binding
GO_0003676Molecular functionnucleic acid binding
GO_0003682Molecular functionchromatin binding
GO_0010484Molecular functionhistone H3 acetyltransferase activity
GO_0004402Molecular functionhistone acetyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMCM3AP
Protein nameGerminal-center associated nuclear protein (GANP) (EC 2.3.1.48) (80 kDa MCM3-associated protein) (MCM3 acetylating protein) (MCM3AP) (EC 2.3.1.-) (MCM3 acetyltransferase)
Alternative protein MCM3AP
Minichromosome maintenance complex component 3 associated protein
SynonymsKIAA0572
GANP
MAP80
DescriptionFUNCTION: [Isoform GANP]: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores . Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations . .; FUNCTION: [Isoform MCM3AP]: Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle . Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations . .

AccessionsO60318
A0A0A0MSZ7
ENST00000291688.6 [O60318-1]
L8ECA8
ENST00000397708.1 [O60318-1]
ENST00000426537.1