Name | Number of supported studies | Average coverage | |
---|---|---|---|
glutamatergic neuron | 9 studies | 38% ± 25% | |
adipocyte | 9 studies | 32% ± 9% | |
astrocyte | 9 studies | 30% ± 13% | |
microglial cell | 8 studies | 25% ± 8% | |
oligodendrocyte | 8 studies | 29% ± 9% | |
oligodendrocyte precursor cell | 8 studies | 27% ± 13% | |
GABAergic neuron | 7 studies | 36% ± 21% | |
endothelial cell | 6 studies | 31% ± 15% | |
epithelial cell | 6 studies | 31% ± 14% | |
type II pneumocyte | 6 studies | 42% ± 10% | |
macrophage | 5 studies | 23% ± 7% | |
neuron | 4 studies | 30% ± 12% | |
ciliated cell | 4 studies | 19% ± 3% | |
type I pneumocyte | 4 studies | 18% ± 4% | |
dendritic cell | 4 studies | 20% ± 4% | |
club cell | 4 studies | 29% ± 11% | |
interneuron | 4 studies | 43% ± 23% | |
abnormal cell | 3 studies | 21% ± 5% | |
fibroblast | 3 studies | 27% ± 15% | |
basal cell | 3 studies | 31% ± 16% | |
transit amplifying cell | 3 studies | 35% ± 20% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
ovary | 100% | 2254.72 | 180 / 180 | 100% | 27.07 | 430 / 430 |
brain | 100% | 1583.11 | 2637 / 2642 | 100% | 28.67 | 705 / 705 |
breast | 100% | 2476.63 | 459 / 459 | 100% | 24.07 | 1113 / 1118 |
pancreas | 100% | 2411.74 | 328 / 328 | 99% | 16.03 | 177 / 178 |
bladder | 100% | 2432.95 | 21 / 21 | 99% | 29.80 | 501 / 504 |
thymus | 100% | 2254.64 | 653 / 653 | 99% | 22.25 | 601 / 605 |
prostate | 100% | 2210.76 | 245 / 245 | 99% | 32.01 | 498 / 502 |
lung | 99% | 2345.14 | 575 / 578 | 99% | 34.68 | 1149 / 1155 |
esophagus | 100% | 1827.36 | 1445 / 1445 | 99% | 24.91 | 181 / 183 |
intestine | 100% | 1683.10 | 966 / 966 | 99% | 19.05 | 520 / 527 |
stomach | 100% | 2373.30 | 359 / 359 | 99% | 18.98 | 282 / 286 |
uterus | 100% | 1552.84 | 170 / 170 | 98% | 26.53 | 452 / 459 |
liver | 100% | 2453.23 | 226 / 226 | 98% | 25.26 | 398 / 406 |
kidney | 100% | 2583.02 | 89 / 89 | 98% | 24.79 | 881 / 901 |
skin | 100% | 1931.64 | 1808 / 1809 | 94% | 17.29 | 446 / 472 |
adrenal gland | 100% | 3326.76 | 258 / 258 | 76% | 10.18 | 175 / 230 |
adipose | 100% | 2638.27 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 23.70 | 29 / 29 |
spleen | 100% | 1466.71 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 32.24 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 7.27 | 1 / 1 |
muscle | 100% | 1475.25 | 802 / 803 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1535.17 | 1332 / 1335 | 0% | 0 | 0 / 0 |
heart | 94% | 1860.13 | 808 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 64% | 6.35 | 51 / 80 |
peripheral blood | 46% | 943.40 | 425 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006768 | Biological process | biotin metabolic process |
GO_0006552 | Biological process | L-leucine catabolic process |
GO_0009083 | Biological process | branched-chain amino acid catabolic process |
GO_1905202 | Cellular component | methylcrotonoyl-CoA carboxylase complex |
GO_0002169 | Cellular component | 3-methylcrotonyl-CoA carboxylase complex, mitochondrial |
GO_0005829 | Cellular component | cytosol |
GO_0005759 | Cellular component | mitochondrial matrix |
GO_0005739 | Cellular component | mitochondrion |
GO_0004075 | Molecular function | biotin carboxylase activity |
GO_0004485 | Molecular function | methylcrotonoyl-CoA carboxylase activity |
GO_0009374 | Molecular function | biotin binding |
GO_0005515 | Molecular function | protein binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0005524 | Molecular function | ATP binding |
Gene name | MCCC1 |
Protein name | Methylcrotonoyl-CoA carboxylase 1 isoform 2 Methylcrotonoyl-Coenzyme A carboxylase 1 (Alpha), isoform CRA_a (Methylcrotonyl-CoA carboxylase subunit 1) Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCase subunit alpha) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (3-methylcrotonyl-CoA carboxylase biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) Methylcrotonoyl-CoA carboxylase 1 isoform 1 Methylcrotonyl-CoA carboxylase subunit 1 |
Synonyms | hCG_1811721 MCCA |
Description | FUNCTION: Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. . |
Accessions | F8WDI3 ENST00000490284.5 E9PG35 Q96RQ3 ENST00000487634.5 ENST00000629669.2 G5E9X5 F2Z2Z7 ENST00000492597.5 ENST00000466650.5 F8WF46 ENST00000497959.5 ENST00000495767.5 A0A0S2Z693 ENST00000486226.1 ENST00000476176.5 E9PHF7 ENST00000265594.9 A0A0S2Z5H8 F2Z3E2 ENST00000497830.5 |