MCCC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006768Biological processbiotin metabolic process
GO_0006552Biological processL-leucine catabolic process
GO_0009083Biological processbranched-chain amino acid catabolic process
GO_1905202Cellular componentmethylcrotonoyl-CoA carboxylase complex
GO_0002169Cellular component3-methylcrotonyl-CoA carboxylase complex, mitochondrial
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0004075Molecular functionbiotin carboxylase activity
GO_0004485Molecular functionmethylcrotonoyl-CoA carboxylase activity
GO_0009374Molecular functionbiotin binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameMCCC1
Protein nameMethylcrotonoyl-CoA carboxylase 1 isoform 2
Methylcrotonoyl-Coenzyme A carboxylase 1 (Alpha), isoform CRA_a (Methylcrotonyl-CoA carboxylase subunit 1)
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCase subunit alpha) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (3-methylcrotonyl-CoA carboxylase biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha)
Methylcrotonoyl-CoA carboxylase 1 isoform 1
Methylcrotonyl-CoA carboxylase subunit 1
SynonymshCG_1811721
MCCA
DescriptionFUNCTION: Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. .

AccessionsF8WDI3
ENST00000490284.5
E9PG35
Q96RQ3
ENST00000487634.5
ENST00000629669.2
G5E9X5
F2Z2Z7
ENST00000492597.5
ENST00000466650.5
F8WF46
ENST00000497959.5
ENST00000495767.5
A0A0S2Z693
ENST00000486226.1
ENST00000476176.5
E9PHF7
ENST00000265594.9
A0A0S2Z5H8
F2Z3E2
ENST00000497830.5