MC4R report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MC4R at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MC4R at tissue level.

III. Associated gene sets

GO_0007188Biological processadenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO_0007631Biological processfeeding behavior
GO_0002024Biological processdiet induced thermogenesis
GO_0032868Biological processresponse to insulin
GO_2000821Biological processregulation of grooming behavior
GO_1990680Biological processresponse to melanocyte-stimulating hormone
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_0030073Biological processinsulin secretion
GO_2000252Biological processnegative regulation of feeding behavior
GO_0045780Biological processpositive regulation of bone resorption
GO_0006112Biological processenergy reserve metabolic process
GO_0019222Biological processregulation of metabolic process
GO_1903998Biological processregulation of eating behavior
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0004977Molecular functionmelanocortin receptor activity
GO_0017046Molecular functionpeptide hormone binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0042923Molecular functionneuropeptide binding
GO_0004980Molecular functionmelanocyte-stimulating hormone receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMC4R
Protein nameMelanocortin receptor 4 (MC4-R)
Mutated melanocortin receptor 4
Melanocortin receptor 4
Synonyms
DescriptionFUNCTION: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). .

FUNCTION: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). .

FUNCTION: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). .

FUNCTION: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). .

FUNCTION: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). .

FUNCTION: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). .

FUNCTION: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). .

FUNCTION: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). .

FUNCTION: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). .

AccessionsA0N0W8
K4MUE5
P32245
K4N7A9
A0N0W7
K4MWA3
ENST00000299766.5
A0N0W6
A0N0W9
K4MWP7
K4MTP3