Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 11 studies | 27% ± 9% | |
astrocyte | 7 studies | 29% ± 12% | |
glutamatergic neuron | 6 studies | 42% ± 23% | |
GABAergic neuron | 6 studies | 40% ± 21% | |
retina horizontal cell | 5 studies | 34% ± 4% | |
neuron | 4 studies | 25% ± 11% | |
oligodendrocyte precursor cell | 4 studies | 26% ± 9% | |
endothelial cell of lymphatic vessel | 4 studies | 24% ± 3% | |
interneuron | 4 studies | 39% ± 18% | |
granule cell | 3 studies | 18% ± 2% | |
macrophage | 3 studies | 22% ± 6% | |
microglial cell | 3 studies | 20% ± 4% | |
epithelial cell | 3 studies | 26% ± 6% | |
oligodendrocyte | 3 studies | 25% ± 6% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 8 studies | 31% ± 15% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2636.81 | 1445 / 1445 | 100% | 26.82 | 183 / 183 |
liver | 100% | 1723.49 | 226 / 226 | 100% | 20.62 | 406 / 406 |
thymus | 100% | 2331.37 | 653 / 653 | 100% | 21.08 | 605 / 605 |
uterus | 100% | 2799.20 | 170 / 170 | 100% | 23.81 | 459 / 459 |
brain | 100% | 4070.16 | 2641 / 2642 | 100% | 27.80 | 705 / 705 |
skin | 100% | 3704.56 | 1808 / 1809 | 100% | 26.66 | 472 / 472 |
prostate | 100% | 2861.93 | 245 / 245 | 100% | 21.67 | 501 / 502 |
ovary | 100% | 3508.44 | 180 / 180 | 100% | 23.72 | 429 / 430 |
breast | 100% | 2362.93 | 459 / 459 | 99% | 25.17 | 1111 / 1118 |
lung | 100% | 2387.76 | 577 / 578 | 99% | 20.48 | 1149 / 1155 |
kidney | 100% | 1954.40 | 89 / 89 | 99% | 18.08 | 894 / 901 |
adrenal gland | 100% | 2094.35 | 258 / 258 | 99% | 30.77 | 228 / 230 |
stomach | 100% | 1904.46 | 359 / 359 | 99% | 15.81 | 283 / 286 |
intestine | 100% | 2135.99 | 963 / 966 | 99% | 13.26 | 521 / 527 |
bladder | 100% | 3170.43 | 21 / 21 | 98% | 20.29 | 496 / 504 |
pancreas | 99% | 1240.35 | 324 / 328 | 99% | 19.50 | 177 / 178 |
adipose | 100% | 2215.91 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 39.43 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 13.97 | 29 / 29 |
muscle | 100% | 3699.95 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 1864.93 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 18.56 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 14.79 | 1 / 1 |
blood vessel | 100% | 2463.35 | 1334 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 98% | 1937.12 | 909 / 929 | 0% | 0 | 0 / 0 |
heart | 98% | 1840.46 | 840 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0001578 | Biological process | microtubule bundle formation |
GO_0046605 | Biological process | regulation of centrosome cycle |
GO_0051301 | Biological process | cell division |
GO_1900227 | Biological process | positive regulation of NLRP3 inflammasome complex assembly |
GO_0035556 | Biological process | intracellular signal transduction |
GO_1904781 | Biological process | positive regulation of protein localization to centrosome |
GO_0043068 | Biological process | positive regulation of programmed cell death |
GO_0045724 | Biological process | positive regulation of cilium assembly |
GO_0044782 | Biological process | cilium organization |
GO_0000226 | Biological process | microtubule cytoskeleton organization |
GO_0006468 | Biological process | protein phosphorylation |
GO_0007399 | Biological process | nervous system development |
GO_0045787 | Biological process | positive regulation of cell cycle |
GO_0030496 | Cellular component | midbody |
GO_0005813 | Cellular component | centrosome |
GO_0005815 | Cellular component | microtubule organizing center |
GO_0043005 | Cellular component | neuron projection |
GO_0030425 | Cellular component | dendrite |
GO_0000930 | Cellular component | gamma-tubulin complex |
GO_0005829 | Cellular component | cytosol |
GO_0015630 | Cellular component | microtubule cytoskeleton |
GO_0005737 | Cellular component | cytoplasm |
GO_0036064 | Cellular component | ciliary basal body |
GO_0043015 | Molecular function | gamma-tubulin binding |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0050321 | Molecular function | tau-protein kinase activity |
GO_0008017 | Molecular function | microtubule binding |
GO_0005524 | Molecular function | ATP binding |
GO_0048156 | Molecular function | tau protein binding |
GO_0008093 | Molecular function | cytoskeletal anchor activity |
GO_0005515 | Molecular function | protein binding |
GO_0043130 | Molecular function | ubiquitin binding |
Gene name | MARK4 |
Protein name | MARK4 protein (Microtubule affinity regulating kinase 4) MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1) Microtubule affinity regulating kinase 4 |
Synonyms | KIAA1860 MARKL1 |
Description | FUNCTION: Serine/threonine-protein kinase . Phosphorylates the microtubule-associated protein MAPT/TAU . Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 . Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles . Required for the initiation of axoneme extension during cilium assembly . Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro . Plays a role in cell cycle progression, specifically in the G1/S checkpoint . Reduces neuronal cell survival . Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation . Involved in NLRP3 positioning along microtubules by mediating NLRP3 recruitment to microtubule organizing center (MTOC) upon inflammasome activation . . |
Accessions | Q6IPE9 K7EN95 ENST00000592762.5 ENST00000592207.5 ENST00000300843.8 [Q96L34-2] K7EK17 Q96L34 ENST00000590909.1 ENST00000262891.9 [Q96L34-1] ENST00000587566.5 K7EKG8 |