MARK4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001578Biological processmicrotubule bundle formation
GO_0046605Biological processregulation of centrosome cycle
GO_0051301Biological processcell division
GO_1900227Biological processpositive regulation of NLRP3 inflammasome complex assembly
GO_0035556Biological processintracellular signal transduction
GO_1904781Biological processpositive regulation of protein localization to centrosome
GO_0043068Biological processpositive regulation of programmed cell death
GO_0045724Biological processpositive regulation of cilium assembly
GO_0044782Biological processcilium organization
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0006468Biological processprotein phosphorylation
GO_0007399Biological processnervous system development
GO_0045787Biological processpositive regulation of cell cycle
GO_0030496Cellular componentmidbody
GO_0005813Cellular componentcentrosome
GO_0005815Cellular componentmicrotubule organizing center
GO_0043005Cellular componentneuron projection
GO_0030425Cellular componentdendrite
GO_0000930Cellular componentgamma-tubulin complex
GO_0005829Cellular componentcytosol
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0036064Cellular componentciliary basal body
GO_0043015Molecular functiongamma-tubulin binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0050321Molecular functiontau-protein kinase activity
GO_0008017Molecular functionmicrotubule binding
GO_0005524Molecular functionATP binding
GO_0048156Molecular functiontau protein binding
GO_0008093Molecular functioncytoskeletal anchor activity
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameMARK4
Protein nameMARK4 protein (Microtubule affinity regulating kinase 4)
MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1)
Microtubule affinity regulating kinase 4
SynonymsKIAA1860
MARKL1
DescriptionFUNCTION: Serine/threonine-protein kinase . Phosphorylates the microtubule-associated protein MAPT/TAU . Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 . Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles . Required for the initiation of axoneme extension during cilium assembly . Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro . Plays a role in cell cycle progression, specifically in the G1/S checkpoint . Reduces neuronal cell survival . Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation . Involved in NLRP3 positioning along microtubules by mediating NLRP3 recruitment to microtubule organizing center (MTOC) upon inflammasome activation . .

AccessionsQ6IPE9
K7EN95
ENST00000592762.5
ENST00000592207.5
ENST00000300843.8 [Q96L34-2]
K7EK17
Q96L34
ENST00000590909.1
ENST00000262891.9 [Q96L34-1]
ENST00000587566.5
K7EKG8