MARCHF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0006897Biological processendocytosis
GO_0140367Biological processantibacterial innate immune response
GO_0044790Biological processsuppression of viral release by host
GO_1905167Biological processpositive regulation of lysosomal protein catabolic process
GO_0140374Biological processantiviral innate immune response
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0010008Cellular componentendosome membrane
GO_0005765Cellular componentlysosomal membrane
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0008270Molecular functionzinc ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMARCHF2
Protein nameRING-type E3 ubiquitin transferase (EC 2.3.2.27)
Membrane associated ring-CH-type finger 2
E3 ubiquitin-protein ligase MARCHF2 (EC 2.3.2.27) (Membrane-associated RING finger protein 2) (Membrane-associated RING-CH protein II) (MARCH-II) (RING finger protein 172) (RING-type E3 ubiquitin transferase MARCHF2)
SynonymsMARCH2
RNF172
HSPC240
DescriptionFUNCTION: E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates . Together with GOPC/CAL mediates the ubiquitination and lysosomal degradation of CFTR . Ubiquitinates and therefore mediates the degradation of DLG1 . Regulates the intracellular trafficking and secretion of alpha1-antitrypsin/SERPINA1 and HP/haptoglobin via ubiquitination and degradation of the cargo receptor ERGIC3 . Negatively regulates the antiviral and antibacterial immune response by repression of the NF-kB and type 1 IFN signaling pathways, via MARCHF2-mediated K48-linked polyubiquitination of IKBKG/NEMO, resulting in its proteasomal degradation . May be involved in endosomal trafficking through interaction with STX6 . .; FUNCTION: (Microbial infection) Positively regulates the degradation of Vesicular stomatitis virus (VSV) G protein via the lysosomal degradation pathway . Represses HIV-1 viral production and may inhibit the translocation of HIV-1 env to the cell surface, resulting in decreased viral cell-cell transmission . .

AccessionsM0R138
ENST00000602117.1 [Q9P0N8-1]
M0R0S4
ENST00000595142.5
M0QXU4
ENST00000381035.8 [Q9P0N8-2]
M0R1P2
Q9P0N8
ENST00000601283.5
ENST00000595213.1
ENST00000601724.5
ENST00000215555.7 [Q9P0N8-1]