MAPK8IP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007254Biological processJNK cascade
GO_0046328Biological processregulation of JNK cascade
GO_0010469Biological processregulation of signaling receptor activity
GO_0032874Biological processpositive regulation of stress-activated MAPK cascade
GO_0048813Biological processdendrite morphogenesis
GO_0060079Biological processexcitatory postsynaptic potential
GO_2000310Biological processregulation of NMDA receptor activity
GO_0051966Biological processregulation of synaptic transmission, glutamatergic
GO_0046958Biological processnonassociative learning
GO_0007172Biological processsignal complex assembly
GO_2000311Biological processregulation of AMPA receptor activity
GO_2001234Biological processnegative regulation of apoptotic signaling pathway
GO_0007617Biological processmating behavior
GO_0001662Biological processbehavioral fear response
GO_0035176Biological processsocial behavior
GO_0032991Cellular componentprotein-containing complex
GO_0043025Cellular componentneuronal cell body
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0008432Molecular functionJUN kinase binding
GO_0005078Molecular functionMAP-kinase scaffold activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0001540Molecular functionamyloid-beta binding
GO_0019901Molecular functionprotein kinase binding
GO_0005198Molecular functionstructural molecule activity
GO_0005515Molecular functionprotein binding
GO_0019894Molecular functionkinesin binding

IV. Literature review

[source]
Gene nameMAPK8IP2
Protein nameC-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2)
Mitogen-activated protein kinase 8 interacting protein 2
SynonymsPRKM8IPL
JIP2
IB2
DescriptionFUNCTION: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). .

AccessionsQ86VW5
Q13387
ENST00000329492.6 [Q13387-1]