MAPK13 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1903936Biological processcellular response to sodium arsenite
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0034644Biological processcellular response to UV
GO_0071347Biological processcellular response to interleukin-1
GO_0072709Biological processcellular response to sorbitol
GO_0006970Biological processresponse to osmotic stress
GO_0072740Biological processcellular response to anisomycin
GO_0051403Biological processstress-activated MAPK cascade
GO_0035556Biological processintracellular signal transduction
GO_0050729Biological processpositive regulation of inflammatory response
GO_0070301Biological processcellular response to hydrogen peroxide
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004707Molecular functionMAP kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMAPK13
Protein nameMitogen-activated protein kinase 13
Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
Mitogen-activated protein kinase 13 (EC 2.7.11.24)
SynonymsPRKM13
SAPK4
DescriptionFUNCTION: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells. .

AccessionsO15264
ENST00000373766.9 [O15264-2]
Q5R3E6
ENST00000211287.9 [O15264-1]
Q6FHR4
ENST00000373759.1
A0A0S2Z542
A0A024RD04
B5BTY5