Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 5 studies | 28% ± 10% | |
| endothelial cell | 4 studies | 21% ± 4% | |
| ciliated cell | 3 studies | 27% ± 6% | |
| macrophage | 3 studies | 16% ± 1% | |
| fibroblast | 3 studies | 22% ± 7% | |
| GABAergic neuron | 3 studies | 22% ± 2% | |
| astrocyte | 3 studies | 17% ± 2% | |
| glutamatergic neuron | 3 studies | 34% ± 6% | |
| basal cell | 3 studies | 20% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 25% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 3127.74 | 1445 / 1445 | 100% | 27.14 | 183 / 183 |
| liver | 100% | 2519.92 | 226 / 226 | 100% | 26.92 | 406 / 406 |
| pancreas | 100% | 2222.23 | 328 / 328 | 100% | 39.01 | 178 / 178 |
| prostate | 100% | 3902.82 | 245 / 245 | 100% | 46.21 | 502 / 502 |
| skin | 100% | 5186.26 | 1809 / 1809 | 100% | 41.56 | 472 / 472 |
| uterus | 100% | 3154.89 | 170 / 170 | 100% | 42.41 | 459 / 459 |
| breast | 100% | 3651.60 | 459 / 459 | 100% | 44.68 | 1117 / 1118 |
| kidney | 100% | 3455.65 | 89 / 89 | 100% | 38.93 | 900 / 901 |
| thymus | 100% | 4031.57 | 653 / 653 | 100% | 40.32 | 604 / 605 |
| lung | 100% | 3325.87 | 576 / 578 | 100% | 37.79 | 1155 / 1155 |
| ovary | 100% | 3779.94 | 180 / 180 | 100% | 25.10 | 428 / 430 |
| brain | 100% | 2911.27 | 2629 / 2642 | 100% | 37.32 | 705 / 705 |
| intestine | 100% | 3138.46 | 966 / 966 | 99% | 32.68 | 524 / 527 |
| bladder | 100% | 3309.86 | 21 / 21 | 99% | 39.00 | 501 / 504 |
| stomach | 100% | 2409.81 | 359 / 359 | 99% | 26.96 | 283 / 286 |
| adrenal gland | 100% | 3824.55 | 258 / 258 | 99% | 33.65 | 227 / 230 |
| adipose | 100% | 3203.40 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 38.27 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 32.55 | 29 / 29 |
| spleen | 100% | 4064.78 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 37.68 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 26.72 | 1 / 1 |
| blood vessel | 100% | 3173.47 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| heart | 99% | 2275.40 | 851 / 861 | 0% | 0 | 0 / 0 |
| muscle | 98% | 1447.30 | 786 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 97% | 2301.38 | 901 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_1904382 | Biological process | mannose trimming involved in glycoprotein ERAD pathway |
| GO_0036508 | Biological process | protein alpha-1,2-demannosylation |
| GO_0006058 | Biological process | mannoprotein catabolic process |
| GO_0009311 | Biological process | oligosaccharide metabolic process |
| GO_0036503 | Biological process | ERAD pathway |
| GO_0019082 | Biological process | viral protein processing |
| GO_0006486 | Biological process | protein glycosylation |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_1903561 | Cellular component | extracellular vesicle |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0031410 | Cellular component | cytoplasmic vesicle |
| GO_0016020 | Cellular component | membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0044322 | Cellular component | endoplasmic reticulum quality control compartment |
| GO_0004571 | Molecular function | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity |
| GO_0005509 | Molecular function | calcium ion binding |
| Gene name | MAN1B1 |
| Protein name | alpha-1,2-Mannosidase (EC 3.2.1.-) Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (EC 3.2.1.113) (ER alpha-1,2-mannosidase) (ER mannosidase 1) (ERMan1) (Man9GlcNAc2-specific-processing alpha-mannosidase) (Mannosidase alpha class 1B member 1) Mannosidase alpha class 1B member 1 |
| Synonyms | UNQ747/PRO1477 hCG_1818277 |
| Description | FUNCTION: Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2). . |
| Accessions | H0YI64 ENST00000683355.1 ENST00000544448.6 ENST00000682212.1 ENST00000684144.1 ENST00000682117.1 A0A804HK01 ENST00000371589.9 A0A087X064 A0A804HJ23 ENST00000683324.1 ENST00000684272.1 A0A804HL61 H0YFU3 ENST00000684366.1 Q9UKM7 ENST00000535144.6 ENST00000475449.7 A0A804HHU1 H0YGQ1 ENST00000684138.1 ENST00000545539.6 B3KQC5 A0A804HJ66 A0A804HL65 ENST00000542372.2 A0A804HIP1 H0YG20 ENST00000684759.1 A0A804HKS1 ENST00000371587.9 ENST00000683979.1 ENST00000682881.1 ENST00000684297.1 A0A804HJW0 H0YGV7 A0A804HK86 ENST00000683987.1 ENST00000683135.1 A0A804HK28 ENST00000683475.1 A0A291FGE6 |
