MALSU1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0090071Biological processnegative regulation of ribosome biogenesis
GO_0042273Biological processribosomal large subunit biogenesis
GO_0070130Biological processnegative regulation of mitochondrial translation
GO_0017148Biological processnegative regulation of translation
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0043023Molecular functionribosomal large subunit binding
GO_0005515Molecular functionprotein binding
GO_0140978Molecular functionmitochondrial large ribosomal subunit binding

IV. Literature review

[source]
Gene nameMALSU1
Protein nameMitochondrial assembly of ribosomal large subunit protein 1
SynonymsC7orf30
DescriptionFUNCTION: Required for normal mitochondrial ribosome function and mitochondrial translation . May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits (Probable). Interacts with mitochondrial ribosomal protein uL14m (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits (Probable). Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes (Probable). May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome . May function as a ribosomal silencing factor (Probable). .

AccessionsENST00000466681.2
Q96EH3