MAJIN report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MAJIN at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MAJIN at tissue level.

III. Associated gene sets

GO_0070197Biological processmeiotic attachment of telomere to nuclear envelope
GO_0007283Biological processspermatogenesis
GO_0048477Biological processoogenesis
GO_1990918Biological processdouble-strand break repair involved in meiotic recombination
GO_0045141Biological processmeiotic telomere clustering
GO_0007129Biological processhomologous chromosome pairing at meiosis
GO_0000781Cellular componentchromosome, telomeric region
GO_0005637Cellular componentnuclear inner membrane
GO_0003677Molecular functionDNA binding

IV. Literature review

[source]
Gene nameMAJIN
Protein nameMembrane anchored junction protein
MAJIN
Membrane-anchored junction protein
SynonymsC11orf85
DescriptionFUNCTION: Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane. .

AccessionsENST00000432175.5 [Q3KP22-3]
ENST00000530735.5
E9PRZ4
Q3KP22
ENST00000301896.6 [Q3KP22-3]
ENST00000530444.5 [Q3KP22-1]
H0YEC1
A0A0P0YTB5
ENST00000532617.5