MACROD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042278Biological processpurine nucleoside metabolic process
GO_0006974Biological processDNA damage response
GO_0051725Biological processprotein de-ADP-ribosylation
GO_0140291Biological processpeptidyl-glutamate ADP-deribosylation
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0140293Molecular functionADP-ribosylglutamate hydrolase activity
GO_0019213Molecular functiondeacetylase activity
GO_0016798Molecular functionhydrolase activity, acting on glycosyl bonds
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMACROD1
Protein nameADP-ribose glycohydrolase MACROD1 (MACRO domain-containing protein 1) (O-acetyl-ADP-ribose deacetylase MACROD1) (EC 3.1.1.106) (Protein LRP16) ([Protein ADP-ribosylaspartate] hydrolase MACROD1) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD1) (EC 3.2.2.-)
Mono-ADP ribosylhydrolase 1
SynonymsLRP16
DescriptionFUNCTION: Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety . Inactive towards proteins bearing poly-ADP-ribose . Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins . Plays a role in estrogen signaling . Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen . May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation . Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction . Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells . Enhances ESR1-mediated transcription activity . .

AccessionsQ9BQ69
A0A6Q8PH91
ENST00000675777.1
ENST00000255681.7