I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| pericyte | 11 studies | 25% ± 8% | |
| endothelial cell | 5 studies | 25% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| pericyte | 11 studies | 25% ± 8% | |
| endothelial cell | 5 studies | 25% ± 5% |
Insufficient scRNA-seq data for expression of LZTS1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 94% | 896.94 | 430 / 459 | 85% | 9.76 | 947 / 1118 |
| skin | 69% | 531.15 | 1253 / 1809 | 100% | 185.87 | 470 / 472 |
| brain | 84% | 3005.14 | 2207 / 2642 | 84% | 22.65 | 593 / 705 |
| lung | 100% | 1878.03 | 576 / 578 | 67% | 6.91 | 769 / 1155 |
| adrenal gland | 77% | 411.95 | 198 / 258 | 85% | 23.18 | 196 / 230 |
| thymus | 94% | 779.95 | 614 / 653 | 65% | 6.71 | 396 / 605 |
| kidney | 87% | 713.83 | 77 / 89 | 66% | 17.49 | 599 / 901 |
| esophagus | 78% | 701.62 | 1132 / 1445 | 65% | 8.62 | 119 / 183 |
| uterus | 95% | 745.75 | 162 / 170 | 43% | 6.94 | 197 / 459 |
| prostate | 93% | 824.64 | 229 / 245 | 35% | 2.17 | 175 / 502 |
| pancreas | 28% | 129.62 | 93 / 328 | 89% | 13.36 | 158 / 178 |
| bladder | 62% | 559.86 | 13 / 21 | 40% | 4.04 | 204 / 504 |
| eye | 0% | 0 | 0 / 0 | 100% | 132.14 | 80 / 80 |
| stomach | 46% | 205.76 | 166 / 359 | 52% | 5.43 | 149 / 286 |
| adipose | 95% | 936.12 | 1141 / 1204 | 0% | 0 | 0 / 0 |
| ovary | 58% | 263.28 | 104 / 180 | 35% | 3.12 | 152 / 430 |
| heart | 81% | 544.62 | 699 / 861 | 0% | 0 | 0 / 0 |
| intestine | 45% | 213.45 | 436 / 966 | 34% | 3.29 | 181 / 527 |
| tonsil | 0% | 0 | 0 / 0 | 56% | 6.63 | 25 / 45 |
| muscle | 50% | 213.67 | 399 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 43% | 273.00 | 578 / 1335 | 0% | 0 | 0 / 0 |
| liver | 4% | 18.09 | 9 / 226 | 26% | 2.16 | 104 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 14% | 0.97 | 4 / 29 |
| spleen | 12% | 56.89 | 30 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 1% | 3.89 | 8 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0048167 | Biological process | regulation of synaptic plasticity |
| GO_0016242 | Biological process | negative regulation of macroautophagy |
| GO_0150052 | Biological process | regulation of postsynapse assembly |
| GO_0048814 | Biological process | regulation of dendrite morphogenesis |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0043197 | Cellular component | dendritic spine |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0014069 | Cellular component | postsynaptic density |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005515 | Molecular function | protein binding |
| Gene name | LZTS1 |
| Protein name | Leucine zipper putative tumor suppressor 1 (F37/esophageal cancer-related gene-coding leucine-zipper motif) (Fez1) |
| Synonyms | FEZ1 |
| Description | FUNCTION: Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. . |
| Accessions | ENST00000381569.5 [Q9Y250-1] ENST00000522290.5 [Q9Y250-4] Q9Y250 ENST00000265801.6 [Q9Y250-1] |
