LURAP1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of LURAP1 at single-cell level.

II. Expression across tissues

III. Associated gene sets

GO_0001819Biological processpositive regulation of cytokine production
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLURAP1
Protein nameLeucine rich adaptor protein 1 (Leucine repeat adapter protein 35A)
SynonymsLRAP35A
C1orf190
LRP35A
DescriptionFUNCTION: Acts as an activator of the canonical NF-kappa-B pathway and drive the production of pro-inflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway . In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity). .

AccessionsQ96LR2
ENST00000371980.4