Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 10 studies | 24% ± 9% | |
| oligodendrocyte | 7 studies | 30% ± 9% | |
| epithelial cell | 5 studies | 31% ± 9% | |
| neuron | 4 studies | 24% ± 9% | |
| microglial cell | 4 studies | 23% ± 4% | |
| macrophage | 4 studies | 20% ± 4% | |
| astrocyte | 4 studies | 32% ± 11% | |
| interneuron | 4 studies | 36% ± 21% | |
| classical monocyte | 3 studies | 16% ± 1% | |
| hematopoietic precursor cell | 3 studies | 16% ± 0% | |
| ciliated cell | 3 studies | 19% ± 3% | |
| lymphocyte | 3 studies | 20% ± 1% | |
| GABAergic neuron | 3 studies | 39% ± 17% | |
| glutamatergic neuron | 3 studies | 45% ± 18% | |
| oligodendrocyte precursor cell | 3 studies | 32% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 2006.15 | 1445 / 1445 | 100% | 20.21 | 183 / 183 |
| ovary | 100% | 2254.24 | 180 / 180 | 100% | 9.54 | 428 / 430 |
| lung | 100% | 1900.71 | 576 / 578 | 99% | 13.48 | 1149 / 1155 |
| prostate | 100% | 2168.08 | 245 / 245 | 99% | 17.49 | 496 / 502 |
| breast | 100% | 2674.74 | 459 / 459 | 99% | 19.25 | 1103 / 1118 |
| brain | 98% | 1444.20 | 2601 / 2642 | 100% | 14.04 | 702 / 705 |
| pancreas | 100% | 2061.20 | 328 / 328 | 97% | 10.19 | 173 / 178 |
| stomach | 100% | 1959.32 | 359 / 359 | 97% | 12.64 | 277 / 286 |
| thymus | 100% | 2301.27 | 653 / 653 | 97% | 11.76 | 585 / 605 |
| bladder | 100% | 2206.67 | 21 / 21 | 96% | 11.39 | 485 / 504 |
| uterus | 100% | 2525.52 | 170 / 170 | 96% | 12.15 | 441 / 459 |
| intestine | 100% | 2169.95 | 966 / 966 | 94% | 10.85 | 493 / 527 |
| adrenal gland | 100% | 2139.31 | 258 / 258 | 93% | 9.07 | 214 / 230 |
| kidney | 100% | 1230.09 | 89 / 89 | 93% | 11.82 | 837 / 901 |
| skin | 100% | 2624.32 | 1809 / 1809 | 90% | 13.54 | 423 / 472 |
| liver | 100% | 1133.36 | 226 / 226 | 75% | 5.51 | 306 / 406 |
| blood vessel | 100% | 2499.59 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 100% | 2126.69 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2022.70 | 241 / 241 | 0% | 0 | 0 / 0 |
| adipose | 100% | 2474.77 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 13.40 | 43 / 45 |
| heart | 94% | 1248.09 | 812 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 83% | 7.85 | 24 / 29 |
| peripheral blood | 69% | 1115.28 | 644 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 61% | 4.61 | 49 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0051865 | Biological process | protein autoubiquitination |
| GO_1990116 | Biological process | ribosome-associated ubiquitin-dependent protein catabolic process |
| GO_0072344 | Biological process | rescue of stalled ribosome |
| GO_1990112 | Cellular component | RQC complex |
| GO_0022626 | Cellular component | cytosolic ribosome |
| GO_0005829 | Cellular component | cytosol |
| GO_0043023 | Molecular function | ribosomal large subunit binding |
| GO_0061630 | Molecular function | ubiquitin protein ligase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0008270 | Molecular function | zinc ion binding |
| Gene name | LTN1 |
| Protein name | E3 ubiquitin-protein ligase listerin (EC 2.3.2.27) (RING finger protein 160) (RING-type E3 ubiquitin transferase listerin) (Zinc finger protein 294) E3 ubiquitin-protein ligase listerin (EC 2.3.2.27) (RING-type E3 ubiquitin transferase listerin) |
| Synonyms | ZNF294 C21orf98 C21orf10 RNF160 KIAA0714 HSPC087 |
| Description | FUNCTION: E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation . Within the RQC complex, LTN1 is recruited to stalled 60S ribosomal subunits by NEMF and mediates ubiquitination of stalled nascent chains . Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity). . FUNCTION: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. . FUNCTION: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. . FUNCTION: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. . |
| Accessions | ENST00000707893.1 [O94822-1] G1UI34 ENST00000389195.7 O94822 ENST00000707894.1 [O94822-1] S4R3T2 ENST00000707899.1 [O94822-3] ENST00000389194.7 [O94822-1] ENST00000361371.10 [O94822-1] ENST00000614971.4 [O94822-3] ENST00000483326.1 H7BYG8 |