LTN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051865Biological processprotein autoubiquitination
GO_1990116Biological processribosome-associated ubiquitin-dependent protein catabolic process
GO_0072344Biological processrescue of stalled ribosome
GO_1990112Cellular componentRQC complex
GO_0022626Cellular componentcytosolic ribosome
GO_0005829Cellular componentcytosol
GO_0043023Molecular functionribosomal large subunit binding
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameLTN1
Protein nameE3 ubiquitin-protein ligase listerin (EC 2.3.2.27) (RING finger protein 160) (RING-type E3 ubiquitin transferase listerin) (Zinc finger protein 294)
E3 ubiquitin-protein ligase listerin (EC 2.3.2.27) (RING-type E3 ubiquitin transferase listerin)
SynonymsZNF294
C21orf98
C21orf10
RNF160
KIAA0714
HSPC087
DescriptionFUNCTION: E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation . Within the RQC complex, LTN1 is recruited to stalled 60S ribosomal subunits by NEMF and mediates ubiquitination of stalled nascent chains . Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity). .

FUNCTION: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. .

FUNCTION: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. .

FUNCTION: E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. .

AccessionsENST00000707893.1 [O94822-1]
G1UI34
ENST00000389195.7
O94822
ENST00000707894.1 [O94822-1]
S4R3T2
ENST00000707899.1 [O94822-3]
ENST00000389194.7 [O94822-1]
ENST00000361371.10 [O94822-1]
ENST00000614971.4 [O94822-3]
ENST00000483326.1
H7BYG8