Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 11 studies | 37% ± 12% | |
| astrocyte | 8 studies | 26% ± 8% | |
| retinal ganglion cell | 6 studies | 71% ± 19% | |
| adipocyte | 6 studies | 27% ± 12% | |
| GABAergic neuron | 4 studies | 35% ± 12% | |
| glutamatergic neuron | 4 studies | 40% ± 17% | |
| epithelial cell | 3 studies | 20% ± 4% | |
| type I pneumocyte | 3 studies | 21% ± 2% | |
| type II pneumocyte | 3 studies | 26% ± 4% | |
| endothelial cell | 3 studies | 30% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 6 studies | 34% ± 13% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 7409.76 | 1445 / 1445 | 100% | 26.55 | 183 / 183 |
| prostate | 100% | 8571.24 | 245 / 245 | 100% | 49.96 | 502 / 502 |
| skin | 100% | 8444.43 | 1809 / 1809 | 100% | 35.76 | 471 / 472 |
| brain | 100% | 6692.57 | 2640 / 2642 | 100% | 54.19 | 704 / 705 |
| intestine | 100% | 5833.66 | 966 / 966 | 99% | 34.19 | 523 / 527 |
| breast | 100% | 6693.10 | 459 / 459 | 99% | 30.52 | 1109 / 1118 |
| adrenal gland | 100% | 10443.43 | 258 / 258 | 99% | 62.71 | 228 / 230 |
| uterus | 100% | 6985.49 | 170 / 170 | 99% | 31.55 | 455 / 459 |
| liver | 100% | 8942.00 | 226 / 226 | 99% | 41.52 | 402 / 406 |
| lung | 100% | 7730.97 | 577 / 578 | 99% | 28.27 | 1140 / 1155 |
| bladder | 100% | 5778.62 | 21 / 21 | 98% | 29.42 | 495 / 504 |
| thymus | 99% | 3595.44 | 649 / 653 | 99% | 18.09 | 597 / 605 |
| pancreas | 99% | 3317.39 | 324 / 328 | 98% | 24.47 | 175 / 178 |
| stomach | 100% | 5314.62 | 358 / 359 | 97% | 27.58 | 277 / 286 |
| kidney | 100% | 3119.88 | 89 / 89 | 95% | 14.20 | 859 / 901 |
| ovary | 100% | 9174.04 | 180 / 180 | 95% | 17.79 | 407 / 430 |
| adipose | 100% | 7850.15 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 5988.81 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 29.89 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 39.63 | 29 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 36.29 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 12.32 | 1 / 1 |
| muscle | 100% | 3760.26 | 800 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2735.31 | 240 / 241 | 0% | 0 | 0 / 0 |
| heart | 99% | 4279.38 | 849 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 39% | 2237.45 | 358 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0031647 | Biological process | regulation of protein stability |
| GO_0006695 | Biological process | cholesterol biosynthetic process |
| GO_0006694 | Biological process | steroid biosynthetic process |
| GO_0016104 | Biological process | triterpenoid biosynthetic process |
| GO_0005811 | Cellular component | lipid droplet |
| GO_0016020 | Cellular component | membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0000250 | Molecular function | lanosterol synthase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | LSS |
| Protein name | Lanosterol synthase (EC 5.4.99.7) (2,3-epoxysqualene--lanosterol cyclase) (Oxidosqualene--lanosterol cyclase) (OSC) (hOSC) Lanosterol synthase |
| Synonyms | OSC |
| Description | FUNCTION: Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus . Through the production of lanosterol may regulate lens protein aggregation and increase transparency . . |
| Accessions | ENST00000457828.6 [P48449-2] A0A0G2JQD0 ENST00000625922.1 ENST00000630761.2 ENST00000522411.5 [P48449-3] ENST00000356396.8 [P48449-1] ENST00000419093.5 P48449 ENST00000630343.2 ENST00000450351.1 ENST00000627118.2 H7C3A5 A0A0G2JS81 ENST00000625576.2 C9J315 ENST00000397728.8 [P48449-1] |
