I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| ciliated cell | 6 studies | 42% ± 20% | |
| GABAergic neuron | 3 studies | 31% ± 10% | |
| glutamatergic neuron | 3 studies | 41% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| ciliated cell | 6 studies | 42% ± 20% | |
| GABAergic neuron | 3 studies | 31% ± 10% | |
| glutamatergic neuron | 3 studies | 41% ± 5% |
Insufficient scRNA-seq data for expression of LRGUK at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 90% | 52.44 | 1621 / 1809 | 67% | 3.33 | 315 / 472 |
| kidney | 100% | 82.48 | 89 / 89 | 45% | 0.84 | 406 / 901 |
| breast | 96% | 73.66 | 439 / 459 | 49% | 1.24 | 546 / 1118 |
| prostate | 98% | 117.84 | 240 / 245 | 29% | 0.46 | 146 / 502 |
| ovary | 72% | 19.63 | 130 / 180 | 47% | 1.00 | 201 / 430 |
| lung | 97% | 100.37 | 562 / 578 | 19% | 0.39 | 216 / 1155 |
| pancreas | 98% | 80.43 | 323 / 328 | 13% | 0.23 | 24 / 178 |
| brain | 80% | 33.50 | 2117 / 2642 | 29% | 0.72 | 204 / 705 |
| thymus | 100% | 102.67 | 652 / 653 | 7% | 0.12 | 44 / 605 |
| uterus | 86% | 36.84 | 147 / 170 | 17% | 0.39 | 80 / 459 |
| esophagus | 76% | 21.61 | 1096 / 1445 | 27% | 0.49 | 49 / 183 |
| bladder | 86% | 22.71 | 18 / 21 | 13% | 0.21 | 63 / 504 |
| stomach | 90% | 33.77 | 324 / 359 | 7% | 0.14 | 21 / 286 |
| adrenal gland | 93% | 46.32 | 241 / 258 | 3% | 0.06 | 8 / 230 |
| spleen | 96% | 88.73 | 232 / 241 | 0% | 0 | 0 / 0 |
| adipose | 94% | 46.64 | 1130 / 1204 | 0% | 0 | 0 / 0 |
| liver | 88% | 38.06 | 198 / 226 | 5% | 0.09 | 22 / 406 |
| intestine | 87% | 34.38 | 844 / 966 | 5% | 0.09 | 28 / 527 |
| blood vessel | 52% | 12.99 | 697 / 1335 | 0% | 0 | 0 / 0 |
| heart | 39% | 8.58 | 338 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 34% | 7.61 | 320 / 929 | 0% | 0 | 0 / 0 |
| muscle | 33% | 7.01 | 263 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 17% | 0.25 | 5 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 2% | 0.03 | 1 / 45 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.03 | 1 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0046037 | Biological process | GMP metabolic process |
| GO_0046710 | Biological process | GDP metabolic process |
| GO_0007283 | Biological process | spermatogenesis |
| GO_0030154 | Biological process | cell differentiation |
| GO_0035082 | Biological process | axoneme assembly |
| GO_0042995 | Cellular component | cell projection |
| GO_0001669 | Cellular component | acrosomal vesicle |
| GO_0005829 | Cellular component | cytosol |
| GO_0002177 | Cellular component | manchette |
| GO_0004385 | Molecular function | guanylate kinase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0005524 | Molecular function | ATP binding |
| Gene name | LRGUK |
| Protein name | Leucine-rich repeat and guanylate kinase domain-containing protein Leucine rich repeats and guanylate kinase domain containing |
| Synonyms | |
| Description | FUNCTION: Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. . |
| Accessions | ENST00000645682.1 ENST00000285928.3 A0A2R8YEJ5 Q96M69 A0A8Q3SIT3 ENST00000695542.2 ENST00000695543.1 A0A8Q3SI13 |
