LRAT | OmnibusX

Name	Number of supported studies	Average coverage
retinal pigment epithelial cell	4 studies	52% ± 15%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of LRAT at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	482.15	652 / 653	89%	4.32	540 / 605
brain	84%	327.43	2222 / 2642	59%	2.96	413 / 705
prostate	93%	395.20	229 / 245	37%	0.89	188 / 502
liver	99%	322.21	224 / 226	22%	1.35	89 / 406
pancreas	72%	64.85	235 / 328	37%	1.93	65 / 178
kidney	38%	38.15	34 / 89	53%	1.69	475 / 901
breast	50%	72.19	229 / 459	39%	1.13	437 / 1118
intestine	82%	361.85	793 / 966	6%	0.16	32 / 527
esophagus	44%	51.71	641 / 1445	38%	4.03	69 / 183
skin	11%	12.03	190 / 1809	60%	4.10	282 / 472
lung	21%	17.08	124 / 578	46%	2.04	529 / 1155
ovary	29%	63.77	53 / 180	37%	0.88	157 / 430
tonsil	0%	0	0 / 0	64%	3.18	29 / 45
stomach	56%	82.33	200 / 359	7%	0.18	19 / 286
bladder	38%	37.14	8 / 21	17%	0.58	88 / 504
uterus	24%	34.17	41 / 170	24%	0.79	110 / 459
adipose	25%	51.40	307 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	23%	0.56	18 / 80
adrenal gland	2%	1.47	4 / 258	14%	0.62	33 / 230
heart	11%	11.36	96 / 861	0%	0	0 / 0
blood vessel	5%	7.33	73 / 1335	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007601	Biological process	visual perception
GO_0009617	Biological process	response to bacterium
GO_1990830	Biological process	cellular response to leukemia inhibitory factor
GO_0033189	Biological process	response to vitamin A
GO_0001523	Biological process	retinoid metabolic process
GO_0006776	Biological process	vitamin A metabolic process
GO_0042572	Biological process	retinol metabolic process
GO_0032370	Biological process	positive regulation of lipid transport
GO_0032526	Biological process	response to retinoic acid
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005771	Cellular component	multivesicular body
GO_0005791	Cellular component	rough endoplasmic reticulum
GO_0016416	Molecular function	O-palmitoyltransferase activity
GO_0102279	Molecular function	lecithin:11-cis retinol acyltransferase activity
GO_0019841	Molecular function	retinol binding
GO_0047173	Molecular function	phosphatidylcholine-retinol O-acyltransferase activity
GO_0016746	Molecular function	acyltransferase activity
GO_0001972	Molecular function	retinoic acid binding
GO_0005515	Molecular function	protein binding

Gene name	LRAT
Protein name	Lecithin retinol acyltransferase Lecithin retinol acyltransferase (EC 2.3.1.135) (Phosphatidylcholine--retinol O-acyltransferase)
Synonyms
Description	FUNCTION: Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters . Retinyl esters are storage forms of vitamin A (Probable). LRAT plays a critical role in vision (Probable). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (Probable). Required for the survival of cone photoreceptors and correct rod photoreceptor cell morphology (By similarity). .
Accessions	ENST00000502525.5 O95237 ENST00000507827.5 D6RC94 ENST00000336356.4

LRAT report