LPCAT3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0036335Biological processintestinal stem cell homeostasis
GO_0036150Biological processphosphatidylserine acyl-chain remodeling
GO_0036151Biological processphosphatidylcholine acyl-chain remodeling
GO_1905885Biological processpositive regulation of triglyceride transport
GO_0090158Biological processendoplasmic reticulum membrane organization
GO_0006656Biological processphosphatidylcholine biosynthetic process
GO_0034379Biological processvery-low-density lipoprotein particle assembly
GO_1903573Biological processnegative regulation of response to endoplasmic reticulum stress
GO_0036152Biological processphosphatidylethanolamine acyl-chain remodeling
GO_0045797Biological processpositive regulation of intestinal cholesterol absorption
GO_0050728Biological processnegative regulation of inflammatory response
GO_0030258Biological processlipid modification
GO_0045540Biological processregulation of cholesterol biosynthetic process
GO_0034378Biological processchylomicron assembly
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0003841Molecular function1-acylglycerol-3-phosphate O-acyltransferase activity
GO_0071617Molecular functionlysophospholipid acyltransferase activity
GO_0106263Molecular function1-acylglycerophosphoserine O-acyltransferase activity
GO_0106262Molecular function1-acylglycerophosphoethanolamine O-acyltransferase activity
GO_0047144Molecular function2-acylglycerol-3-phosphate O-acyltransferase activity
GO_0047184Molecular function1-acylglycerophosphocholine O-acyltransferase activity

IV. Literature review

[source]
Gene nameLPCAT3
Protein nameLysophosphatidylcholine acyltransferase 3
Lysophospholipid acyltransferase 5 (EC 2.3.1.23) (EC 2.3.1.n6)
Lysophospholipid acyltransferase 5 (LPLAT 5) (EC 2.3.1.-) (1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) (1-acylglycerophosphoethanolamine O-acyltransferase) (EC 2.3.1.n7) (1-acylglycerophosphoserine O-acyltransferase) (EC 2.3.1.n6) (Lysophosphatidylcholine acyltransferase) (LPCAT) (Lyso-PC acyltransferase) (Lysophosphatidylcholine acyltransferase 3) (Lyso-PC acyltransferase 3) (Lysophosphatidylserine acyltransferase) (LPSAT) (Lyso-PS acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 5) (O-acyltransferase domain-containing protein 5)
Lysophosphatidylcholine acyltransferase 3 (cDNA FLJ59910, highly similar to Membrane bound O-acyltransferase domain-containing protein 5)
SynonymsOACT5
MBOAT5
DescriptionFUNCTION: Lysophospholipid O-acyltransferase (LPLAT) that catalyzes the reacylation step of the phospholipid remodeling process also known as the Lands cycle . Catalyzes transfer of the fatty acyl chain from fatty acyl-CoA to 1-acyl lysophospholipid to form various classes of phospholipids. Converts 1-acyl lysophosphatidylcholine (LPC) into phosphatidylcholine (PC) (LPCAT activity), 1-acyl lysophosphatidylserine (LPS) into phosphatidylserine (PS) (LPSAT activity) and 1-acyl lysophosphatidylethanolamine (LPE) into phosphatidylethanolamine (PE) (LPEAT activity) . Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs . Has higher activity for LPC acyl acceptors compared to LPEs and LPSs. Can also transfer the fatty acyl chain from fatty acyl-CoA to 1-O-alkyl lysophospholipid or 1-O-alkenyl lysophospholipid with lower efficiency (By similarity). Acts as a major LPC O-acyltransferase in liver and intestine. As a component of the liver X receptor/NR1H3 or NR1H2 signaling pathway, mainly catalyzes the incorporation of arachidonate into PCs of endoplasmic reticulum (ER) membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Promotes processing of sterol regulatory protein SREBF1 in hepatocytes, likely by facilitating the translocation of SREBF1-SCAP complex from ER to the Golgi apparatus (By similarity). Participates in mechanisms by which the liver X receptor/NR1H3 or NR1H2 signaling pathway counteracts lipid-induced ER stress response and inflammation. Down-regulates hepatic inflammation by limiting arachidonic acid availability for synthesis of inflammatory eicosanoids, such as prostaglandins (By similarity). In enterocytes, acts as a component of a gut-brain feedback loop that coordinates dietary lipid absorption and food intake. Regulates the abundance of PCs containing linoleate and arachidonate in enterocyte membranes, enabling passive diffusion of fatty acids and cholesterol across the membrane for efficient chylomicron assembly (By similarity). In the intestinal crypt, acts as a component of dietary-responsive phospholipid-cholesterol axis, regulating the biosynthesis of cholesterol and its mitogenic effects on intestinal stem cells (By similarity). .

AccessionsF5H0M4
ENST00000261407.9 [Q6P1A2-1]
ENST00000536797.5
ENST00000535479.5
Q6P1A2
F5GYT3
F5H680
ENST00000538910.1
F5H7K7
ENST00000543794.5
B7Z3N5
ENST00000540090.5