LIN28B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000627Biological processpositive regulation of miRNA catabolic process
GO_0050779Biological processRNA destabilization
GO_2000632Biological processnegative regulation of pre-miRNA processing
GO_0031054Biological processpre-miRNA processing
GO_0010587Biological processmiRNA catabolic process
GO_2000635Biological processnegative regulation of primary miRNA processing
GO_0031123Biological processRNA 3'-end processing
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding
GO_0008270Molecular functionzinc ion binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameLIN28B
Protein nameLIN28B protein
Protein lin-28 homolog B (Lin-28B)
Lin-28 homolog B
SynonymsCSDD2
DescriptionFUNCTION: Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA . Does not act on pri-miR21 . The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation . This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent . Interaction with target pre-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop. Mediates MYC-induced let-7 repression (By similarity). When overexpressed, isoform 1 stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth. .

AccessionsA0A1B0GVD3
A7E2T3
A0A1B0GTK2
ENST00000345080.5 [Q6ZN17-1]
ENST00000635857.1
ENST00000637759.1
Q6ZN17