LIMK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1902018Biological processnegative regulation of cilium assembly
GO_0007283Biological processspermatogenesis
GO_0060322Biological processhead development
GO_0061303Biological processcornea development in camera-type eye
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0030036Biological processactin cytoskeleton organization
GO_0030953Biological processastral microtubule organization
GO_0016310Biological processphosphorylation
GO_0006468Biological processprotein phosphorylation
GO_0051650Biological processestablishment of vesicle localization
GO_1900182Biological processpositive regulation of protein localization to nucleus
GO_0005801Cellular componentcis-Golgi network
GO_0072686Cellular componentmitotic spindle
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005813Cellular componentcentrosome
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLIMK2
Protein nameLIM domain kinase 2
Protein phosphatase 1 regulatory subunit 14
Alternative protein LIMK2
LIM domain kinase 2 (LIMK-2) (EC 2.7.11.1)
LIM domain kinase 2 (EC 2.7.11.1)
Synonyms
DescriptionFUNCTION: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics . Acts downstream of several Rho family GTPase signal transduction pathways . Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP . Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro . Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 . .

FUNCTION: Inhibitor of PPP1CA. .

AccessionsP53671
ENST00000331728.9 [P53671-1]
C9JK61
B5BU33
ENST00000333611.8 [P53671-2]
ENST00000340552.4 [P53671-3]
L8E888
ENST00000406516.5
ENST00000425203.1
B5MC51
L8E7T4