Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 17 studies | 25% ± 8% | |
ciliated cell | 10 studies | 26% ± 10% | |
endothelial cell of lymphatic vessel | 8 studies | 32% ± 15% | |
epithelial cell | 7 studies | 26% ± 5% | |
basal cell | 7 studies | 28% ± 12% | |
microglial cell | 5 studies | 22% ± 5% | |
macrophage | 5 studies | 23% ± 9% | |
monocyte | 4 studies | 21% ± 5% | |
respiratory goblet cell | 4 studies | 39% ± 14% | |
type I pneumocyte | 4 studies | 20% ± 3% | |
glutamatergic neuron | 4 studies | 25% ± 11% | |
goblet cell | 4 studies | 27% ± 12% | |
astrocyte | 4 studies | 32% ± 9% | |
neutrophil | 3 studies | 22% ± 10% | |
secretory cell | 3 studies | 20% ± 3% | |
endothelial cell of vascular tree | 3 studies | 29% ± 18% | |
GABAergic neuron | 3 studies | 29% ± 10% | |
endothelial cell of artery | 3 studies | 25% ± 8% | |
alveolar macrophage | 3 studies | 26% ± 4% | |
transit amplifying cell | 3 studies | 33% ± 16% | |
oligodendrocyte | 3 studies | 17% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 5156.10 | 459 / 459 | 100% | 52.26 | 1116 / 1118 |
thymus | 100% | 7097.91 | 653 / 653 | 100% | 44.46 | 603 / 605 |
esophagus | 100% | 4719.72 | 1439 / 1445 | 100% | 46.32 | 183 / 183 |
uterus | 100% | 3337.12 | 170 / 170 | 100% | 60.73 | 457 / 459 |
ovary | 100% | 3210.48 | 180 / 180 | 100% | 53.61 | 428 / 430 |
prostate | 100% | 6167.04 | 245 / 245 | 99% | 39.19 | 499 / 502 |
stomach | 100% | 3967.27 | 358 / 359 | 100% | 36.62 | 285 / 286 |
intestine | 100% | 4454.14 | 965 / 966 | 99% | 40.23 | 524 / 527 |
lung | 100% | 7611.26 | 577 / 578 | 99% | 50.85 | 1144 / 1155 |
brain | 96% | 3158.86 | 2535 / 2642 | 100% | 31.90 | 702 / 705 |
pancreas | 97% | 2574.63 | 317 / 328 | 99% | 40.73 | 176 / 178 |
bladder | 95% | 2745.24 | 20 / 21 | 100% | 46.64 | 503 / 504 |
kidney | 100% | 3811.65 | 89 / 89 | 94% | 22.50 | 843 / 901 |
skin | 94% | 7038.71 | 1692 / 1809 | 93% | 28.18 | 438 / 472 |
adrenal gland | 99% | 2246.97 | 256 / 258 | 79% | 16.27 | 182 / 230 |
liver | 64% | 2820.97 | 145 / 226 | 65% | 15.48 | 263 / 406 |
lymph node | 0% | 0 | 0 / 0 | 100% | 30.51 | 29 / 29 |
spleen | 100% | 6585.73 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 62.29 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 36.26 | 1 / 1 |
peripheral blood | 100% | 16864.58 | 928 / 929 | 0% | 0 | 0 / 0 |
adipose | 99% | 2903.29 | 1197 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 98% | 2362.89 | 1307 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 75% | 11.43 | 60 / 80 |
heart | 75% | 1211.20 | 642 / 861 | 0% | 0 | 0 / 0 |
muscle | 71% | 1553.00 | 568 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_1902018 | Biological process | negative regulation of cilium assembly |
GO_0007283 | Biological process | spermatogenesis |
GO_0060322 | Biological process | head development |
GO_0061303 | Biological process | cornea development in camera-type eye |
GO_0001934 | Biological process | positive regulation of protein phosphorylation |
GO_0030036 | Biological process | actin cytoskeleton organization |
GO_0030953 | Biological process | astral microtubule organization |
GO_0016310 | Biological process | phosphorylation |
GO_0006468 | Biological process | protein phosphorylation |
GO_0051650 | Biological process | establishment of vesicle localization |
GO_1900182 | Biological process | positive regulation of protein localization to nucleus |
GO_0005801 | Cellular component | cis-Golgi network |
GO_0072686 | Cellular component | mitotic spindle |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0005813 | Cellular component | centrosome |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
Gene name | LIMK2 |
Protein name | LIM domain kinase 2 Protein phosphatase 1 regulatory subunit 14 Alternative protein LIMK2 LIM domain kinase 2 (LIMK-2) (EC 2.7.11.1) LIM domain kinase 2 (EC 2.7.11.1) |
Synonyms | |
Description | FUNCTION: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics . Acts downstream of several Rho family GTPase signal transduction pathways . Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP . Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro . Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 . . FUNCTION: Inhibitor of PPP1CA. . |
Accessions | P53671 ENST00000331728.9 [P53671-1] C9JK61 B5BU33 ENST00000333611.8 [P53671-2] ENST00000340552.4 [P53671-3] L8E888 ENST00000406516.5 ENST00000425203.1 B5MC51 L8E7T4 |