LAS1L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000460Biological processmaturation of 5.8S rRNA
GO_0006364Biological processrRNA processing
GO_0000470Biological processmaturation of LSU-rRNA
GO_0030687Cellular componentpreribosome, large subunit precursor
GO_0005730Cellular componentnucleolus
GO_0090730Cellular componentLas1 complex
GO_0005654Cellular componentnucleoplasm
GO_0071339Cellular componentMLL1 complex
GO_0016020Cellular componentmembrane
GO_0004519Molecular functionendonuclease activity
GO_0005515Molecular functionprotein binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameLAS1L
Protein nameRibosomal biogenesis protein LAS1L (Endoribonuclease LAS1L) (EC 3.1.-.-) (Protein LAS1 homolog)
LAS1 like ribosome biogenesis factor
SynonymsMSTP060
DescriptionFUNCTION: Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA . Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes . Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) . .

AccessionsENST00000469091.1
A0A7I2V5R7
A0A7I2V4E5
ENST00000374804.9 [Q9Y4W2-3]
A0A7I2V3R6
R4GNF7
ENST00000678956.1
ENST00000484069.1 [Q9Y4W2-4]
ENST00000374811.8 [Q9Y4W2-1]
ENST00000677969.1
Q9Y4W2
ENST00000677087.1
ENST00000374807.9 [Q9Y4W2-2]
A0A7I2V653
A0A7I2V3Q3
ENST00000678823.1
A0A7I2V4V0
ENST00000676986.1
ENST00000677056.1
A0A7I2YQI7
ENST00000678570.1