I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 4 studies | 38% ± 10% | |
| non-classical monocyte | 3 studies | 19% ± 5% | |
| GABAergic neuron | 3 studies | 30% ± 12% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 4 studies | 38% ± 10% | |
| non-classical monocyte | 3 studies | 19% ± 5% | |
| GABAergic neuron | 3 studies | 30% ± 12% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 29% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 957.10 | 245 / 245 | 100% | 13.48 | 501 / 502 |
| thymus | 100% | 984.53 | 653 / 653 | 98% | 8.68 | 590 / 605 |
| breast | 100% | 967.54 | 459 / 459 | 95% | 6.50 | 1066 / 1118 |
| esophagus | 100% | 430.93 | 1439 / 1445 | 96% | 6.32 | 175 / 183 |
| lung | 100% | 778.15 | 577 / 578 | 95% | 6.19 | 1093 / 1155 |
| bladder | 100% | 755.43 | 21 / 21 | 94% | 6.92 | 473 / 504 |
| intestine | 100% | 685.96 | 966 / 966 | 91% | 6.16 | 478 / 527 |
| kidney | 100% | 618.56 | 89 / 89 | 90% | 6.07 | 814 / 901 |
| brain | 93% | 361.12 | 2463 / 2642 | 97% | 4.93 | 682 / 705 |
| stomach | 98% | 435.26 | 353 / 359 | 90% | 5.75 | 256 / 286 |
| ovary | 100% | 1299.84 | 180 / 180 | 87% | 4.31 | 375 / 430 |
| uterus | 100% | 1470.34 | 170 / 170 | 85% | 5.70 | 392 / 459 |
| pancreas | 88% | 230.77 | 287 / 328 | 97% | 7.66 | 172 / 178 |
| skin | 100% | 656.42 | 1808 / 1809 | 83% | 4.67 | 393 / 472 |
| adrenal gland | 100% | 1850.53 | 258 / 258 | 82% | 5.15 | 189 / 230 |
| liver | 97% | 408.68 | 219 / 226 | 44% | 1.83 | 177 / 406 |
| spleen | 100% | 1633.25 | 241 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 907.77 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 100% | 852.24 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| peripheral blood | 95% | 577.49 | 881 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 90% | 7.71 | 26 / 29 |
| muscle | 87% | 221.14 | 698 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 87% | 3.62 | 39 / 45 |
| heart | 83% | 241.87 | 717 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 51% | 1.86 | 41 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006325 | Biological process | chromatin organization |
| GO_0030851 | Biological process | granulocyte differentiation |
| GO_0030225 | Biological process | macrophage differentiation |
| GO_2000060 | Biological process | positive regulation of ubiquitin-dependent protein catabolic process |
| GO_0043249 | Biological process | erythrocyte maturation |
| GO_0090308 | Biological process | regulation of DNA methylation-dependent heterochromatin formation |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0140034 | Molecular function | methylation-dependent protein binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0042393 | Molecular function | histone binding |
| GO_0003682 | Molecular function | chromatin binding |
| Gene name | L3MBTL3 |
| Protein name | Lethal(3)malignant brain tumor-like protein 3 (H-l(3)mbt-like protein 3) (L(3)mbt-like protein 3) (L3mbt-like 3) (MBT-1) L3MBTL histone methyl-lysine binding protein 3 |
| Synonyms | MBT1 KIAA1798 |
| Description | FUNCTION: Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression . It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation . Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins . Required for normal maturation of myeloid progenitor cells (By similarity). . |
| Accessions | ENST00000674039.1 E9PLL7 Q96JM7 ENST00000526019.5 [Q96JM7-2] ENST00000361794.7 [Q96JM7-1] A0A669KAX0 E9PI01 ENST00000368136.3 [Q96JM7-1] ENST00000533560.5 [Q96JM7-2] ENST00000528385.5 ENST00000368139.6 [Q96JM7-2] ENST00000526087.5 |
