Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| basal cell | 21 studies | 62% ± 25% | |
| epithelial cell | 8 studies | 58% ± 28% | |
| secretory cell | 7 studies | 48% ± 21% | |
| squamous epithelial cell | 4 studies | 44% ± 25% | |
| ciliated cell | 4 studies | 38% ± 15% | |
| myoepithelial cell | 4 studies | 82% ± 14% | |
| hillock cell | 3 studies | 58% ± 31% | |
| smooth muscle cell | 3 studies | 37% ± 3% | |
| keratinocyte | 3 studies | 26% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 91% | 12247.66 | 222 / 245 | 35% | 138.05 | 175 / 502 |
| bladder | 52% | 4457.29 | 11 / 21 | 61% | 1873.00 | 308 / 504 |
| esophagus | 32% | 7082.15 | 458 / 1445 | 70% | 2554.67 | 129 / 183 |
| ureter | 0% | 0 | 0 / 0 | 100% | 873.76 | 1 / 1 |
| tonsil | 0% | 0 | 0 / 0 | 93% | 3599.55 | 42 / 45 |
| breast | 63% | 32538.01 | 287 / 459 | 25% | 180.99 | 285 / 1118 |
| skin | 75% | 37041.84 | 1354 / 1809 | 11% | 337.68 | 54 / 472 |
| uterus | 4% | 402.56 | 7 / 170 | 76% | 3695.01 | 347 / 459 |
| pancreas | 1% | 19.52 | 3 / 328 | 69% | 856.47 | 122 / 178 |
| lung | 15% | 596.20 | 86 / 578 | 46% | 1446.59 | 531 / 1155 |
| blood vessel | 35% | 1276.38 | 471 / 1335 | 0% | 0 | 0 / 0 |
| ovary | 1% | 25.73 | 2 / 180 | 16% | 49.30 | 68 / 430 |
| thymus | 1% | 57.98 | 4 / 653 | 11% | 74.58 | 65 / 605 |
| intestine | 0% | 15.20 | 4 / 966 | 10% | 83.23 | 54 / 527 |
| stomach | 2% | 47.93 | 6 / 359 | 8% | 38.51 | 23 / 286 |
| kidney | 4% | 97.96 | 4 / 89 | 3% | 20.82 | 25 / 901 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 6.69 | 1 / 29 |
| brain | 2% | 42.21 | 58 / 2642 | 0% | 0 | 0 / 705 |
| adipose | 2% | 207.98 | 25 / 1204 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 2% | 8.43 | 8 / 406 |
| adrenal gland | 0% | 0 | 0 / 258 | 0% | 5.08 | 1 / 230 |
| peripheral blood | 0% | 71.72 | 3 / 929 | 0% | 0 | 0 / 0 |
| muscle | 0% | 12.28 | 1 / 803 | 0% | 0 | 0 / 0 |
| heart | 0% | 59.22 | 1 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| GO_0031069 | Biological process | hair follicle morphogenesis |
| GO_0045109 | Biological process | intermediate filament organization |
| GO_0031424 | Biological process | keratinization |
| GO_0030307 | Biological process | positive regulation of cell growth |
| GO_0045727 | Biological process | positive regulation of translation |
| GO_0030855 | Biological process | epithelial cell differentiation |
| GO_0051798 | Biological process | positive regulation of hair follicle development |
| GO_0001533 | Cellular component | cornified envelope |
| GO_0045111 | Cellular component | intermediate filament cytoskeleton |
| GO_0005856 | Cellular component | cytoskeleton |
| GO_0005829 | Cellular component | cytosol |
| GO_0045095 | Cellular component | keratin filament |
| GO_0005515 | Molecular function | protein binding |
| GO_0005198 | Molecular function | structural molecule activity |
| Gene name | KRT17 |
| Protein name | Keratin 17 Keratin, type I cytoskeletal 17 (39.1) (Cytokeratin-17) (CK-17) (Keratin-17) (K17) Keratin, type I cytoskeletal 17 (Cytokeratin-17) (Keratin-17) |
| Synonyms | |
| Description | FUNCTION: Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors (By similarity). May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. . |
| Accessions | ENST00000577817.3 A0A3B3IS58 K7EPJ9 ENST00000463128.5 K7ESE1 ENST00000648859.1 Q04695 ENST00000311208.13 |
