KREMEN2 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of KREMEN2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	80%	344.61	1444 / 1809	68%	7.59	321 / 472
brain	85%	81.02	2256 / 2642	58%	3.15	410 / 705
prostate	87%	124.17	212 / 245	50%	2.05	250 / 502
esophagus	38%	57.27	554 / 1445	63%	16.50	116 / 183
tonsil	0%	0	0 / 0	98%	46.22	44 / 45
lymph node	0%	0	0 / 0	93%	15.77	27 / 29
uterus	12%	10.08	21 / 170	78%	14.16	358 / 459
ovary	3%	0.66	5 / 180	86%	15.81	370 / 430
intestine	37%	19.93	361 / 966	43%	2.79	229 / 527
breast	20%	7.04	90 / 459	48%	4.12	540 / 1118
lung	17%	5.03	101 / 578	46%	9.60	536 / 1155
spleen	59%	20.85	142 / 241	0%	0	0 / 0
adrenal gland	32%	8.30	82 / 258	24%	2.13	56 / 230
stomach	15%	4.25	54 / 359	35%	1.84	99 / 286
eye	0%	0	0 / 0	46%	3.15	37 / 80
bladder	0%	0	0 / 21	41%	3.45	209 / 504
pancreas	11%	3.20	37 / 328	24%	1.22	42 / 178
peripheral blood	31%	31.68	291 / 929	0%	0	0 / 0
thymus	4%	1.76	25 / 653	16%	19.59	95 / 605
kidney	10%	4.57	9 / 89	3%	0.17	25 / 901
muscle	12%	3.52	99 / 803	0%	0	0 / 0
adipose	12%	3.69	146 / 1204	0%	0	0 / 0
liver	2%	0.61	4 / 226	7%	0.37	29 / 406
heart	3%	0.73	26 / 861	0%	0	0 / 0
blood vessel	1%	0.63	19 / 1335	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0030279	Biological process	negative regulation of ossification
GO_0060173	Biological process	limb development
GO_0007275	Biological process	multicellular organism development
GO_0016055	Biological process	Wnt signaling pathway
GO_0031901	Cellular component	early endosome membrane
GO_0005886	Cellular component	plasma membrane

Gene name	KREMEN2
Protein name	Kremen protein 2 (Dickkopf receptor 2) (Kringle domain-containing transmembrane protein 2) (Kringle-containing protein marking the eye and the nose)
Synonyms	KRM2
Description	FUNCTION: Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. .
Accessions	ENST00000572045.5 [Q8NCW0-4] ENST00000575885.5 [Q8NCW0-6] Q8NCW0 ENST00000303746.10 [Q8NCW0-1] ENST00000319500.11 [Q8NCW0-3] ENST00000575769.1 [Q8NCW0-2] ENST00000571007.5 [Q8NCW0-5]

KREMEN2 report