KPNA5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006606Biological processprotein import into nucleus
GO_0006607Biological processNLS-bearing protein import into nucleus
GO_0042564Cellular componentNLS-dependent protein nuclear import complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0008139Molecular functionnuclear localization sequence binding
GO_0005515Molecular functionprotein binding
GO_0061608Molecular functionnuclear import signal receptor activity

IV. Literature review

[source]
Gene nameKPNA5
Protein nameImportin subunit alpha
Importin subunit alpha-6 (Karyopherin subunit alpha-5)
Karyopherin subunit alpha 5
Synonyms
DescriptionFUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

FUNCTION: Functions in nuclear protein import. .

FUNCTION: Functions in nuclear protein import. .

FUNCTION: Functions in nuclear protein import. .

AccessionsA0A8V8TL68
ENST00000697697.1
O15131
Q5TD90
ENST00000697696.1
A0A8V8TLL2
ENST00000356348.6
ENST00000368564.7
ENST00000697698.1
A0A8V8TL88
A0A8V8TMV2
ENST00000413340.5
ENST00000697699.1