Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 8 studies | 25% ± 10% | |
glutamatergic neuron | 8 studies | 40% ± 25% | |
astrocyte | 8 studies | 32% ± 13% | |
GABAergic neuron | 7 studies | 41% ± 21% | |
oligodendrocyte precursor cell | 7 studies | 32% ± 14% | |
interneuron | 6 studies | 38% ± 22% | |
oligodendrocyte | 6 studies | 25% ± 7% | |
microglial cell | 4 studies | 23% ± 3% | |
neuron | 4 studies | 26% ± 9% | |
epithelial cell | 4 studies | 24% ± 10% | |
retina horizontal cell | 4 studies | 21% ± 6% | |
endothelial cell of lymphatic vessel | 4 studies | 18% ± 1% | |
pericyte | 4 studies | 23% ± 3% | |
GABAergic interneuron | 3 studies | 21% ± 5% | |
retinal cone cell | 3 studies | 22% ± 3% | |
ciliated cell | 3 studies | 24% ± 1% | |
rod bipolar cell | 3 studies | 23% ± 5% | |
adipocyte | 3 studies | 18% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 1603.78 | 2640 / 2642 | 100% | 8.30 | 705 / 705 |
thymus | 100% | 1685.56 | 653 / 653 | 100% | 6.18 | 602 / 605 |
prostate | 100% | 1275.34 | 245 / 245 | 98% | 4.18 | 493 / 502 |
breast | 100% | 1142.34 | 459 / 459 | 97% | 3.48 | 1085 / 1118 |
lung | 100% | 1074.05 | 576 / 578 | 97% | 3.05 | 1115 / 1155 |
esophagus | 100% | 825.28 | 1438 / 1445 | 95% | 3.12 | 174 / 183 |
adrenal gland | 100% | 931.11 | 258 / 258 | 94% | 4.20 | 217 / 230 |
kidney | 100% | 804.15 | 89 / 89 | 94% | 3.50 | 846 / 901 |
uterus | 100% | 1851.01 | 170 / 170 | 91% | 3.02 | 418 / 459 |
ovary | 100% | 2751.05 | 180 / 180 | 90% | 2.35 | 388 / 430 |
pancreas | 93% | 424.16 | 306 / 328 | 93% | 2.71 | 166 / 178 |
bladder | 100% | 1245.14 | 21 / 21 | 86% | 2.27 | 433 / 504 |
stomach | 97% | 696.06 | 350 / 359 | 83% | 2.01 | 236 / 286 |
skin | 100% | 768.50 | 1802 / 1809 | 80% | 2.46 | 377 / 472 |
intestine | 100% | 1011.78 | 962 / 966 | 75% | 1.71 | 395 / 527 |
liver | 66% | 214.78 | 149 / 226 | 38% | 0.73 | 153 / 406 |
blood vessel | 100% | 1117.13 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 1244.00 | 241 / 241 | 0% | 0 | 0 / 0 |
adipose | 100% | 1069.57 | 1201 / 1204 | 0% | 0 | 0 / 0 |
muscle | 99% | 906.99 | 798 / 803 | 0% | 0 | 0 / 0 |
heart | 95% | 526.02 | 820 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 93% | 2.22 | 27 / 29 |
tonsil | 0% | 0 | 0 / 0 | 82% | 1.97 | 37 / 45 |
eye | 0% | 0 | 0 / 0 | 48% | 1.02 | 38 / 80 |
peripheral blood | 39% | 302.34 | 364 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0006606 | Biological process | protein import into nucleus |
GO_0006607 | Biological process | NLS-bearing protein import into nucleus |
GO_0042564 | Cellular component | NLS-dependent protein nuclear import complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005634 | Cellular component | nucleus |
GO_0008139 | Molecular function | nuclear localization sequence binding |
GO_0005515 | Molecular function | protein binding |
GO_0061608 | Molecular function | nuclear import signal receptor activity |
Gene name | KPNA5 |
Protein name | Importin subunit alpha Importin subunit alpha-6 (Karyopherin subunit alpha-5) Karyopherin subunit alpha 5 |
Synonyms | |
Description | FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. FUNCTION: Functions in nuclear protein import. . FUNCTION: Functions in nuclear protein import. . FUNCTION: Functions in nuclear protein import. . |
Accessions | A0A8V8TL68 ENST00000697697.1 O15131 Q5TD90 ENST00000697696.1 A0A8V8TLL2 ENST00000356348.6 ENST00000368564.7 ENST00000697698.1 A0A8V8TL88 A0A8V8TMV2 ENST00000413340.5 ENST00000697699.1 |