I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 5 studies | 24% ± 9% | |
| B cell | 4 studies | 17% ± 1% | |
| endothelial cell | 3 studies | 23% ± 8% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 5 studies | 24% ± 9% | |
| B cell | 4 studies | 17% ± 1% | |
| endothelial cell | 3 studies | 23% ± 8% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 19% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 6458.57 | 1445 / 1445 | 100% | 40.47 | 183 / 183 |
| skin | 100% | 7580.56 | 1809 / 1809 | 100% | 24.96 | 471 / 472 |
| prostate | 100% | 7835.67 | 245 / 245 | 100% | 20.58 | 500 / 502 |
| pancreas | 100% | 4968.53 | 328 / 328 | 99% | 22.55 | 177 / 178 |
| breast | 100% | 6599.11 | 459 / 459 | 99% | 23.51 | 1111 / 1118 |
| uterus | 100% | 7587.45 | 170 / 170 | 99% | 26.54 | 456 / 459 |
| thymus | 100% | 9170.95 | 653 / 653 | 99% | 18.86 | 601 / 605 |
| ovary | 100% | 8112.67 | 180 / 180 | 99% | 29.59 | 427 / 430 |
| stomach | 100% | 5457.75 | 359 / 359 | 99% | 26.78 | 284 / 286 |
| intestine | 100% | 7038.43 | 966 / 966 | 99% | 25.42 | 523 / 527 |
| bladder | 100% | 6637.71 | 21 / 21 | 99% | 24.99 | 500 / 504 |
| lung | 100% | 6631.87 | 578 / 578 | 99% | 25.77 | 1142 / 1155 |
| adrenal gland | 100% | 5478.61 | 258 / 258 | 98% | 16.57 | 226 / 230 |
| kidney | 100% | 5505.20 | 89 / 89 | 97% | 14.66 | 873 / 901 |
| liver | 100% | 3351.09 | 226 / 226 | 94% | 14.30 | 383 / 406 |
| brain | 95% | 3462.21 | 2504 / 2642 | 99% | 20.88 | 701 / 705 |
| adipose | 100% | 5824.48 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 20.80 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 24.36 | 29 / 29 |
| spleen | 100% | 9020.06 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 25.67 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 16.19 | 1 / 1 |
| blood vessel | 100% | 5809.70 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 100% | 4465.77 | 802 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 98% | 5669.17 | 914 / 929 | 0% | 0 | 0 / 0 |
| heart | 97% | 2923.23 | 838 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0032259 | Biological process | methylation |
| GO_0006338 | Biological process | chromatin remodeling |
| GO_0044665 | Cellular component | MLL1/2 complex |
| GO_0035097 | Cellular component | histone methyltransferase complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0140999 | Molecular function | histone H3K4 trimethyltransferase activity |
| GO_0042800 | Molecular function | histone H3K4 methyltransferase activity |
| GO_0140945 | Molecular function | histone H3K4 monomethyltransferase activity |
| GO_0045322 | Molecular function | unmethylated CpG binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0008270 | Molecular function | zinc ion binding |
| Gene name | KMT2B |
| Protein name | Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7) Lysine methyltransferase 2B [histone H3]-lysine(4) N-methyltransferase (EC 2.1.1.364) |
| Synonyms | KIAA0304 MLL4 WBP7 HRX2 MLL2 TRX2 |
| Description | FUNCTION: Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place . Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements . Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 . Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (By similarity). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (By similarity). . |
| Accessions | ENST00000690290.1 A0A8I5QJW0 A0A8I5KXU7 ENST00000693677.1 ENST00000685609.1 A0A8I5KU66 A0A8I5KWS6 A0A8I5KPK0 A0A669KAX8 A0A8I5KRR3 A0A8I5KWL4 A0A8I5KR41 A0A8I5KY89 ENST00000689864.1 A0A8I5KX30 A0A8I5QL11 A0A8I5KX31 ENST00000673918.2 ENST00000693161.1 ENST00000691968.1 A0A8I5KUC7 ENST00000674101.1 ENST00000674114.2 ENST00000692961.1 ENST00000686920.1 Q9UMN6 ENST00000691421.1 A0A8I5KVT4 ENST00000689139.1 A0A8I5KWP7 ENST00000687718.1 A0A8I5KZ64 ENST00000693175.1 A0A669KBI7 ENST00000689929.1 ENST00000685168.1 A0A8I5KUL1 ENST00000673946.1 A0A8I5KTD0 A0A669KB23 ENST00000691855.1 ENST00000693540.1 ENST00000690487.1 ENST00000684977.1 ENST00000420124.4 A0A669KBD5 |
