KLK8 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of KLK8 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KLK8 at tissue level.

III. Associated gene sets

GO_0048812Biological processneuron projection morphogenesis
GO_0007613Biological processmemory
GO_0050807Biological processregulation of synapse organization
GO_0050808Biological processsynapse organization
GO_0009611Biological processresponse to wounding
GO_0006508Biological processproteolysis
GO_0043616Biological processkeratinocyte proliferation
GO_0097180Cellular componentserine protease inhibitor complex
GO_0005615Cellular componentextracellular space
GO_0030141Cellular componentsecretory granule
GO_0005576Cellular componentextracellular region
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding
GO_0004252Molecular functionserine-type endopeptidase activity

IV. Literature review

[source]
Gene nameKLK8
Protein nameKallikrein-8 isoform 12
Kallikrein-8 isoform 9
KLK8 protein type 1
Kallikrein-8 isoform 13
Kallikrein-related peptidase 8 transcript variant 15
Kallikrein-8 isoform 8
Kallikrein 8
KLK8 protein type 2
Kallikrein-8 (hK8) (EC 3.4.21.118) (Neuropsin) (NP) (Ovasin) (Serine protease 19) (Serine protease TADG-14) (Tumor-associated differentially expressed gene 14 protein)
Kallikrein-8 isoform 10
Kallikrein-8 isoform 11
Kallikrein-8 isoform 6
Kallikrein related peptidase 8
Kallikrein-8 isoform 7
SynonymsTADG14
UNQ283/PRO322
HNP
NRPN
NP
PRSS19
DescriptionFUNCTION: Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. .

AccessionsA0A2H4GDC2
ENST00000695909.1 [O60259-1]
M0R390
ENST00000347619.8 [O60259-3]
ENST00000320838.9 [O60259-4]
ENST00000600767.5 [O60259-1]
Q2XQG5
B3FQ94
A0A2H4GDC1
A0A2H4GDA8
ENST00000594669.1
ENST00000291726.11
ENST00000595238.1
ENST00000391806.6 [O60259-2]
A0A2H4GDB8
ENST00000593490.1 [O60259-4]
A0A2H4GDB9
O60259
A0A2H4GDB3
A0A2H4GDC0
B3FQ95
A0A2H4GDC4
M0R231
A0A0A0MQY9
A0A2I2MQ02