Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte | 10 studies | 31% ± 10% | |
glutamatergic neuron | 9 studies | 41% ± 25% | |
endothelial cell | 6 studies | 27% ± 7% | |
endothelial cell of lymphatic vessel | 6 studies | 34% ± 11% | |
Mueller cell | 5 studies | 21% ± 5% | |
GABAergic neuron | 5 studies | 45% ± 21% | |
astrocyte | 5 studies | 27% ± 9% | |
oligodendrocyte precursor cell | 5 studies | 24% ± 8% | |
kidney distal convoluted tubule epithelial cell | 4 studies | 50% ± 9% | |
cardiac muscle cell | 4 studies | 25% ± 3% | |
interneuron | 4 studies | 42% ± 22% | |
granule cell | 3 studies | 33% ± 5% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 8 studies | 40% ± 19% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
thymus | 100% | 3421.26 | 652 / 653 | 97% | 5.11 | 588 / 605 |
adrenal gland | 100% | 2342.24 | 258 / 258 | 92% | 3.17 | 211 / 230 |
brain | 100% | 4210.65 | 2633 / 2642 | 89% | 2.79 | 627 / 705 |
breast | 99% | 1442.57 | 453 / 459 | 75% | 1.84 | 839 / 1118 |
bladder | 100% | 1147.10 | 21 / 21 | 68% | 1.79 | 342 / 504 |
esophagus | 96% | 958.88 | 1389 / 1445 | 68% | 1.48 | 125 / 183 |
lung | 95% | 1035.93 | 551 / 578 | 69% | 1.57 | 794 / 1155 |
ovary | 100% | 1826.16 | 180 / 180 | 63% | 1.38 | 269 / 430 |
kidney | 100% | 2308.30 | 89 / 89 | 62% | 3.86 | 555 / 901 |
pancreas | 63% | 384.02 | 205 / 328 | 94% | 4.16 | 168 / 178 |
intestine | 96% | 942.10 | 929 / 966 | 58% | 1.59 | 306 / 527 |
stomach | 94% | 825.04 | 339 / 359 | 60% | 1.40 | 171 / 286 |
prostate | 100% | 1174.06 | 245 / 245 | 49% | 0.85 | 247 / 502 |
uterus | 100% | 1513.90 | 170 / 170 | 49% | 1.19 | 225 / 459 |
skin | 70% | 519.76 | 1263 / 1809 | 44% | 0.90 | 206 / 472 |
spleen | 100% | 1428.84 | 241 / 241 | 0% | 0 | 0 / 0 |
heart | 98% | 3486.42 | 844 / 861 | 0% | 0 | 0 / 0 |
adipose | 98% | 1385.72 | 1177 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 95% | 1127.89 | 1264 / 1335 | 0% | 0 | 0 / 0 |
liver | 54% | 369.57 | 122 / 226 | 35% | 1.05 | 142 / 406 |
lymph node | 0% | 0 | 0 / 0 | 72% | 1.77 | 21 / 29 |
eye | 0% | 0 | 0 / 0 | 64% | 2.14 | 51 / 80 |
muscle | 42% | 244.76 | 338 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 24% | 0.31 | 11 / 45 |
peripheral blood | 22% | 383.97 | 209 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0070294 | Biological process | renal sodium ion absorption |
GO_0016567 | Biological process | protein ubiquitination |
GO_0010467 | Biological process | gene expression |
GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
GO_0016236 | Biological process | macroautophagy |
GO_0050801 | Biological process | monoatomic ion homeostasis |
GO_0070936 | Biological process | protein K48-linked ubiquitination |
GO_0072156 | Biological process | distal tubule morphogenesis |
GO_0055075 | Biological process | potassium ion homeostasis |
GO_0043161 | Biological process | proteasome-mediated ubiquitin-dependent protein catabolic process |
GO_0005856 | Cellular component | cytoskeleton |
GO_0005829 | Cellular component | cytosol |
GO_0031463 | Cellular component | Cul3-RING ubiquitin ligase complex |
GO_1990756 | Molecular function | ubiquitin-like ligase-substrate adaptor activity |
GO_0005515 | Molecular function | protein binding |
GO_0003779 | Molecular function | actin binding |
GO_0097602 | Molecular function | cullin family protein binding |
GO_0005198 | Molecular function | structural molecule activity |
Gene name | KLHL3 |
Protein name | KLHL3 protein Kelch like family member 3 Kelch-like protein 3 |
Synonyms | KIAA1129 |
Description | FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron . The BCR(KLHL3) complex acts by mediating ubiquitination and degradation of WNK1 and WNK4, two activators of Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney, thereby regulating NaCl reabsorption . The BCR(KLHL3) complex also mediates ubiquitination and degradation of WNK3 . The BCR(KLHL3) complex also mediates ubiquitination of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney, leading to its degradation (By similarity). . |
Accessions | ENST00000508657.5 [Q9UH77-2] ENST00000504208.5 ENST00000506491.5 [Q9UH77-3] Q8N4I8 ENST00000309755.9 [Q9UH77-1] Q9UH77 D6RH21 D6R9K4 ENST00000505853.1 Q49A42 |