KLHL3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070294Biological processrenal sodium ion absorption
GO_0016567Biological processprotein ubiquitination
GO_0010467Biological processgene expression
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0016236Biological processmacroautophagy
GO_0050801Biological processmonoatomic ion homeostasis
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0072156Biological processdistal tubule morphogenesis
GO_0055075Biological processpotassium ion homeostasis
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005856Cellular componentcytoskeleton
GO_0005829Cellular componentcytosol
GO_0031463Cellular componentCul3-RING ubiquitin ligase complex
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding
GO_0097602Molecular functioncullin family protein binding
GO_0005198Molecular functionstructural molecule activity

IV. Literature review

[source]
Gene nameKLHL3
Protein nameKLHL3 protein
Kelch like family member 3
Kelch-like protein 3
SynonymsKIAA1129
DescriptionFUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron . The BCR(KLHL3) complex acts by mediating ubiquitination and degradation of WNK1 and WNK4, two activators of Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney, thereby regulating NaCl reabsorption . The BCR(KLHL3) complex also mediates ubiquitination and degradation of WNK3 . The BCR(KLHL3) complex also mediates ubiquitination of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney, leading to its degradation (By similarity). .

AccessionsENST00000508657.5 [Q9UH77-2]
ENST00000504208.5
ENST00000506491.5 [Q9UH77-3]
Q8N4I8
ENST00000309755.9 [Q9UH77-1]
Q9UH77
D6RH21
D6R9K4
ENST00000505853.1
Q49A42