KLHL22 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030307Biological processpositive regulation of cell growth
GO_0000070Biological processmitotic sister chromatid segregation
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0051301Biological processcell division
GO_0032480Biological processnegative regulation of type I interferon production
GO_0071230Biological processcellular response to amino acid stimulus
GO_0010507Biological processnegative regulation of autophagy
GO_0006513Biological processprotein monoubiquitination
GO_0007094Biological processmitotic spindle assembly checkpoint signaling
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0071233Biological processcellular response to L-leucine
GO_0072686Cellular componentmitotic spindle
GO_0005827Cellular componentpolar microtubule
GO_0005813Cellular componentcentrosome
GO_0005764Cellular componentlysosome
GO_0031463Cellular componentCul3-RING ubiquitin ligase complex
GO_0045171Cellular componentintercellular bridge
GO_0005829Cellular componentcytosol
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005634Cellular componentnucleus
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0071889Molecular function14-3-3 protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKLHL22
Protein nameKelch-like protein 22
Kelch like family member 22
Synonyms
DescriptionFUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation . The BCR(KLHL22) ubiquitin ligase complex is also responsible for the amino acid-stimulated 'Lys-48' polyubiquitination and proteasomal degradation of DEPDC5. Through the degradation of DEPDC5, releases the GATOR1 complex-mediated inhibition of the TORC1 pathway. It is therefore an amino acid-dependent activator within the amino acid-sensing branch of the TORC1 pathway, indirectly regulating different cellular processes including cell growth and autophagy . .

AccessionsENST00000328879.9 [Q53GT1-1]
ENST00000458248.5
C9J5F8
C9JLE9
C9J2T1
ENST00000451553.1
ENST00000444967.5
Q53GT1
C9J191
C9JHG1
C9JRG9
ENST00000423364.1
ENST00000443285.5
ENST00000431430.1