KLHL18 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901992Biological processpositive regulation of mitotic cell cycle phase transition
GO_0051301Biological processcell division
GO_0016567Biological processprotein ubiquitination
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKLHL18
Protein nameKelch like family member 18
Kelch-like protein 18
Kelch-like 18
KLHL18 protein
SynonymsKIAA0795
OK/SW-cl.74
DescriptionFUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis . The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading to its activation at the centrosome which is required for initiating mitotic entry . Regulates light-and dark-dependent alpha-transducin localization changes in rod photoreceptors through UNC119 ubiquitination and degradation (By similarity). Preferentially ubiquitinates the unphosphorylated form of UNC119 over the phosphorylated form (By similarity). In the presence of UNC119, under dark-adapted conditions alpha-transducin mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light (By similarity). .

AccessionsENST00000437353.5
F8WCL4
F8WF78
Q96B51
Q6PJF0
ENST00000433449.5
Q647K1
O94889
ENST00000232766.6 [O94889-1]
ENST00000442272.1
C9J4G4