KLHL17 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of KLHL17 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KLHL17 at tissue level.

III. Associated gene sets

GO_0030036Biological processactin cytoskeleton organization
GO_0016567Biological processprotein ubiquitination
GO_0140252Biological processregulation protein catabolic process at postsynapse
GO_0098978Cellular componentglutamatergic synapse
GO_0005615Cellular componentextracellular space
GO_0015629Cellular componentactin cytoskeleton
GO_0032839Cellular componentdendrite cytoplasm
GO_0043025Cellular componentneuronal cell body
GO_0014069Cellular componentpostsynaptic density
GO_0031208Molecular functionPOZ domain binding
GO_0051015Molecular functionactin filament binding
GO_0005515Molecular functionprotein binding
GO_0060090Molecular functionmolecular adaptor activity

IV. Literature review

[source]
Gene nameKLHL17
Protein nameKelch like family member 17
KLHL17 protein (Kelch-like 17 (Drosophila), isoform CRA_c)
Kelch-like protein 17 (Actinfilin)
KLHL17 protein
SynonymsAF
hCG_31732
DescriptionFUNCTION: Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. The BCR(KLHL17) complex mediates the ubiquitination and subsequent degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity). .

AccessionsENST00000466300.1
ENST00000338591.8
J3QLT4
Q86XA8
Q6TDP4
Q0VGE6