Insufficient scRNA-seq data for expression of KLB at tissue level.
Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 2008.20 | 226 / 226 | 92% | 32.12 | 374 / 406 |
| pancreas | 100% | 500.88 | 328 / 328 | 19% | 0.56 | 34 / 178 |
| breast | 82% | 1056.77 | 378 / 459 | 32% | 0.84 | 359 / 1118 |
| adipose | 97% | 1619.85 | 1172 / 1204 | 0% | 0 | 0 / 0 |
| lung | 47% | 78.81 | 273 / 578 | 15% | 1.17 | 176 / 1155 |
| skin | 53% | 65.82 | 963 / 1809 | 1% | 0.02 | 4 / 472 |
| brain | 51% | 68.02 | 1354 / 2642 | 0% | 0.01 | 3 / 705 |
| intestine | 39% | 73.77 | 378 / 966 | 5% | 0.19 | 28 / 527 |
| esophagus | 30% | 35.94 | 431 / 1445 | 5% | 0.47 | 10 / 183 |
| kidney | 17% | 17.96 | 15 / 89 | 11% | 0.83 | 100 / 901 |
| prostate | 1% | 1.82 | 3 / 245 | 24% | 2.21 | 122 / 502 |
| stomach | 16% | 20.20 | 58 / 359 | 5% | 0.31 | 14 / 286 |
| tonsil | 0% | 0 | 0 / 0 | 18% | 0.25 | 8 / 45 |
| blood vessel | 17% | 63.80 | 222 / 1335 | 0% | 0 | 0 / 0 |
| bladder | 10% | 14.00 | 2 / 21 | 6% | 0.12 | 28 / 504 |
| adrenal gland | 8% | 9.50 | 20 / 258 | 2% | 0.67 | 5 / 230 |
| thymus | 9% | 19.30 | 59 / 653 | 0% | 0.01 | 2 / 605 |
| heart | 8% | 12.44 | 65 / 861 | 0% | 0 | 0 / 0 |
| uterus | 1% | 0.49 | 1 / 170 | 7% | 0.12 | 31 / 459 |
| muscle | 4% | 3.66 | 29 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.04 | 1 / 29 |
| peripheral blood | 1% | 0.79 | 12 / 929 | 0% | 0 | 0 / 0 |
| ovary | 0% | 0 | 0 / 180 | 1% | 0.03 | 5 / 430 |
| spleen | 0% | 3.35 | 1 / 241 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0005975 | Biological process | carbohydrate metabolic process |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0090080 | Biological process | positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005104 | Molecular function | fibroblast growth factor receptor binding |
| GO_0017134 | Molecular function | fibroblast growth factor binding |
| GO_0004553 | Molecular function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| GO_0005515 | Molecular function | protein binding |
| Gene name | KLB |
| Protein name | Beta-klotho (BKL) (BetaKlotho) (Klotho beta-like protein) KLB protein |
| Synonyms | |
| Description | FUNCTION: Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity). . |
| Accessions | Q49AQ7 Q86Z14 B7ZL50 ENST00000257408.5 |
