KIF20B report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KIF20B at tissue level.

III. Associated gene sets

GO_2000114Biological processregulation of establishment of cell polarity
GO_2001224Biological processpositive regulation of neuron migration
GO_0051301Biological processcell division
GO_1903438Biological processpositive regulation of mitotic cytokinetic process
GO_0048812Biological processneuron projection morphogenesis
GO_0035372Biological processprotein localization to microtubule
GO_0007018Biological processmicrotubule-based movement
GO_0001843Biological processneural tube closure
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0090316Biological processpositive regulation of intracellular protein transport
GO_0032467Biological processpositive regulation of cytokinesis
GO_0051726Biological processregulation of cell cycle
GO_0007088Biological processregulation of mitotic nuclear division
GO_0005730Cellular componentnucleolus
GO_0097431Cellular componentmitotic spindle pole
GO_0030496Cellular componentmidbody
GO_0005874Cellular componentmicrotubule
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0005871Cellular componentkinesin complex
GO_1990023Cellular componentmitotic spindle midzone
GO_0045171Cellular componentintercellular bridge
GO_0070938Cellular componentcontractile ring
GO_0051233Cellular componentspindle midzone
GO_0005829Cellular componentcytosol
GO_0030426Cellular componentgrowth cone
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0008574Molecular functionplus-end-directed microtubule motor activity
GO_0050699Molecular functionWW domain binding
GO_0003777Molecular functionmicrotubule motor activity
GO_0008017Molecular functionmicrotubule binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameKIF20B
Protein nameKinesin family member 20B
Kinesin-like protein KIF20B (Cancer/testis antigen 90) (CT90) (Kinesin family member 20B) (Kinesin-related motor interacting with PIN1) (M-phase phosphoprotein 1) (MPP1)
SynonymsMPHOSPH1
KRMP1
DescriptionFUNCTION: Plus-end-directed motor enzyme that is required for completion of cytokinesis . Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression . .

AccessionsENST00000260753.8 [Q96Q89-3]
Q96Q89
ENST00000447580.1
A0A0A0MSJ5
ENST00000371728.8 [Q96Q89-1]