KEAP1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KEAP1 at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0001701Biological processin utero embryonic development
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_1902883Biological processnegative regulation of response to oxidative stress
GO_0045604Biological processregulation of epidermal cell differentiation
GO_0071353Biological processcellular response to interleukin-4
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0034599Biological processcellular response to oxidative stress
GO_0010506Biological processregulation of autophagy
GO_0030496Cellular componentmidbody
GO_0034451Cellular componentcentriolar satellite
GO_0005654Cellular componentnucleoplasm
GO_0031463Cellular componentCul3-RING ubiquitin ligase complex
GO_0005884Cellular componentactin filament
GO_0016234Cellular componentinclusion body
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0008134Molecular functiontranscription factor binding
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0042802Molecular functionidentical protein binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0097718Molecular functiondisordered domain specific binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKEAP1
Protein nameKelch-like ECH-associated protein 1
Kelch like ECH associated protein 1
Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) (Kelch-like protein 19)
SynonymsKIAA0132
KLHL19
INRF2
DescriptionFUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination . KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes . In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting NFE2L2/NRF2 nuclear accumulation and expression of phase II detoxifying enzymes . In response to selective autophagy, KEAP1 is sequestered in inclusion bodies following its interaction with SQSTM1/p62, leading to inactivation of the BCR(KEAP1) complex and activation of NFE2L2/NRF2 . The BCR(KEAP1) complex also mediates ubiquitination of SQSTM1/p62, increasing SQSTM1/p62 sequestering activity and degradation . The BCR(KEAP1) complex also targets BPTF and PGAM5 for ubiquitination and degradation by the proteasome . .

AccessionsENST00000591039.1
ENST00000171111.10
ENST00000585845.1
ENST00000590593.1
K7EQX2
Q14145
K7ESE0
ENST00000592055.2
K7EPZ3
K7EJD8
ENST00000393623.6
ENST00000591419.2
K7EMY1
K7EJ49
ENST00000592478.5