KDM1B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006338Biological processchromatin remodeling
GO_0044726Biological processepigenetic programing of female pronucleus
GO_0071514Biological processgenomic imprinting
GO_0005654Cellular componentnucleoplasm
GO_0000786Cellular componentnucleosome
GO_0005634Cellular componentnucleus
GO_0008134Molecular functiontranscription factor binding
GO_0032452Molecular functionhistone demethylase activity
GO_0071949Molecular functionFAD binding
GO_0016491Molecular functionoxidoreductase activity
GO_0140682Molecular functionFAD-dependent H3K4me/H3K4me3 demethylase activity
GO_0050660Molecular functionflavin adenine dinucleotide binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0042393Molecular functionhistone binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameKDM1B
Protein nameAOF1 protein (Lysine demethylase 1B)
Lysine-specific histone demethylase 2 (EC 1.14.99.66) (Flavin-containing amine oxidase domain-containing protein 1) (Lysine-specific histone demethylase 1B)
Lysine demethylase 1B
SynonymsAOF1
LSD2
C6orf193
DescriptionFUNCTION: Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of GLYR1 to achieve such activity, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes . .

AccessionsQ08EI0
ENST00000449850.2
ENST00000297792.9 [Q8NB78-2]
ENST00000650836.2 [Q8NB78-1]
ENST00000546309.6
H0Y6H0
Q8NB78