KCNJ5 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of KCNJ5 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of KCNJ5 at tissue level.

III. Associated gene sets

GO_0034765Biological processregulation of monoatomic ion transmembrane transport
GO_0098914Biological processmembrane repolarization during atrial cardiac muscle cell action potential
GO_0006813Biological processpotassium ion transport
GO_0098915Biological processmembrane repolarization during ventricular cardiac muscle cell action potential
GO_0086091Biological processregulation of heart rate by cardiac conduction
GO_0099625Biological processventricular cardiac muscle cell membrane repolarization
GO_1990573Biological processpotassium ion import across plasma membrane
GO_0071805Biological processpotassium ion transmembrane transport
GO_0005886Cellular componentplasma membrane
GO_0008076Cellular componentvoltage-gated potassium channel complex
GO_1990566Cellular componentI(KACh) inward rectifier potassium channel complex
GO_0015467Molecular functionG-protein activated inward rectifier potassium channel activity
GO_0086089Molecular functionvoltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
GO_0005515Molecular functionprotein binding
GO_0005242Molecular functioninward rectifier potassium channel activity
GO_1902282Molecular functionvoltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

IV. Literature review

[source]
Gene nameKCNJ5
Protein nameG protein-activated inward rectifier potassium channel 4 (Cardiac inward rectifier) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5)
G protein-activated inward rectifier potassium channel 4
G protein-activated inward rectifier potassium channel 4 (GIRK-4) (Cardiac inward rectifier) (CIR) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (IRK-4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5)
SynonymsGIRK4
DescriptionFUNCTION: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. .

AccessionsH7CGH0
P48544
H9A8K9
ENST00000338350.4
H9A8L0
ENST00000529694.6
Q4QRJ2
ENST00000533599.1
A0A5J6E2W8