Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| erythroblast | 5 studies | 42% ± 16% | |
| retinal bipolar neuron | 4 studies | 33% ± 10% | |
| rod bipolar cell | 3 studies | 27% ± 8% | |
| GABAergic neuron | 3 studies | 28% ± 8% | |
| erythrocyte | 3 studies | 53% ± 26% | |
| mast cell | 3 studies | 29% ± 8% |
Insufficient scRNA-seq data for expression of KCNH2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 86% | 2897.99 | 2285 / 2642 | 99% | 29.10 | 699 / 705 |
| prostate | 92% | 2483.81 | 226 / 245 | 92% | 10.60 | 462 / 502 |
| intestine | 81% | 5646.29 | 786 / 966 | 69% | 9.26 | 366 / 527 |
| ovary | 46% | 567.13 | 82 / 180 | 87% | 15.63 | 376 / 430 |
| uterus | 92% | 3265.91 | 157 / 170 | 38% | 12.55 | 174 / 459 |
| bladder | 90% | 3091.10 | 19 / 21 | 38% | 5.87 | 191 / 504 |
| stomach | 58% | 2468.29 | 207 / 359 | 68% | 10.95 | 194 / 286 |
| adrenal gland | 19% | 287.79 | 48 / 258 | 91% | 95.37 | 210 / 230 |
| esophagus | 64% | 2344.65 | 919 / 1445 | 38% | 4.43 | 70 / 183 |
| heart | 95% | 6081.44 | 815 / 861 | 0% | 0 | 0 / 0 |
| pancreas | 9% | 87.79 | 31 / 328 | 70% | 12.50 | 125 / 178 |
| lung | 26% | 262.49 | 152 / 578 | 42% | 6.90 | 486 / 1155 |
| kidney | 0% | 0 | 0 / 89 | 30% | 4.17 | 274 / 901 |
| breast | 1% | 9.60 | 4 / 459 | 21% | 3.05 | 239 / 1118 |
| spleen | 18% | 189.26 | 43 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 16% | 193.89 | 146 / 929 | 0% | 0 | 0 / 0 |
| skin | 1% | 7.36 | 14 / 1809 | 13% | 2.13 | 59 / 472 |
| liver | 0% | 3.18 | 1 / 226 | 10% | 1.69 | 39 / 406 |
| thymus | 0% | 20.61 | 2 / 653 | 9% | 3.21 | 53 / 605 |
| tonsil | 0% | 0 | 0 / 0 | 9% | 0.95 | 4 / 45 |
| blood vessel | 8% | 226.64 | 101 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 7% | 0.50 | 2 / 29 |
| adipose | 5% | 90.07 | 61 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 3% | 0.67 | 2 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_1901381 | Biological process | positive regulation of potassium ion transmembrane transport |
| GO_0060307 | Biological process | regulation of ventricular cardiac muscle cell membrane repolarization |
| GO_0071466 | Biological process | cellular response to xenobiotic stimulus |
| GO_0042391 | Biological process | regulation of membrane potential |
| GO_1901379 | Biological process | regulation of potassium ion transmembrane transport |
| GO_1903765 | Biological process | negative regulation of potassium ion export across plasma membrane |
| GO_1901380 | Biological process | negative regulation of potassium ion transmembrane transport |
| GO_0086011 | Biological process | membrane repolarization during action potential |
| GO_0086005 | Biological process | ventricular cardiac muscle cell action potential |
| GO_0098915 | Biological process | membrane repolarization during ventricular cardiac muscle cell action potential |
| GO_0086013 | Biological process | membrane repolarization during cardiac muscle cell action potential |
| GO_0055075 | Biological process | potassium ion homeostasis |
| GO_0060048 | Biological process | cardiac muscle contraction |
| GO_0071805 | Biological process | potassium ion transmembrane transport |
| GO_0060306 | Biological process | regulation of membrane repolarization |
| GO_0097623 | Biological process | potassium ion export across plasma membrane |
| GO_0003064 | Biological process | regulation of heart rate by hormone |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0086091 | Biological process | regulation of heart rate by cardiac conduction |
| GO_0086010 | Biological process | membrane depolarization during action potential |
| GO_0086009 | Biological process | membrane repolarization |
| GO_1990573 | Biological process | potassium ion import across plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_1902937 | Cellular component | inward rectifier potassium channel complex |
| GO_0009986 | Cellular component | cell surface |
| GO_0008076 | Cellular component | voltage-gated potassium channel complex |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0005249 | Molecular function | voltage-gated potassium channel activity |
| GO_0005251 | Molecular function | delayed rectifier potassium channel activity |
| GO_0055131 | Molecular function | C3HC4-type RING finger domain binding |
| GO_0000976 | Molecular function | transcription cis-regulatory region binding |
| GO_1902282 | Molecular function | voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0031625 | Molecular function | ubiquitin protein ligase binding |
| GO_0086008 | Molecular function | voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization |
| GO_0097110 | Molecular function | scaffold protein binding |
| GO_0005242 | Molecular function | inward rectifier potassium channel activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | KCNH2 |
| Protein name | Uncharacterized protein KCNH2 Potassium channel HERG1 Potassium voltage-gated channel subfamily H member 2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Voltage-gated potassium channel subunit Kv11.1) Potassium voltage-gated channel subfamily H member 2 (Ether-a-go-go-related gene potassium channel 1) (Voltage-gated potassium channel subunit Kv11.1) Voltage-gated channel subfamily H member 2 Potassium channel HERG |
| Synonyms | ERG1 ERG HERG hCG_18699 tcag7.786 |
| Description | FUNCTION: Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) . .; FUNCTION: [Isoform A-USO]: Has no channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. .; FUNCTION: [Isoform B-USO]: Has no channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. . |
| Accessions | ENST00000262186.10 [Q12809-1] A0A090N7X5 Q6U279 Q6U283 Q75MK9 Q6U287 J9SM79 A0PJW5 Q75MK8 ENST00000330883.9 [Q12809-2] Q45QN5 A0A090N7W1 A8WBZ2 C7DYB4 Q12809 A0A090N8Q0 |
