KCNC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0006813Biological processpotassium ion transport
GO_0071805Biological processpotassium ion transmembrane transport
GO_0051262Biological processprotein tetramerization
GO_0001508Biological processaction potential
GO_0030866Biological processcortical actin cytoskeleton organization
GO_0005856Cellular componentcytoskeleton
GO_0005886Cellular componentplasma membrane
GO_0043204Cellular componentperikaryon
GO_0043679Cellular componentaxon terminus
GO_0032809Cellular componentneuronal cell body membrane
GO_0042734Cellular componentpresynaptic membrane
GO_0030425Cellular componentdendrite
GO_0005938Cellular componentcell cortex
GO_0032591Cellular componentdendritic spine membrane
GO_0045211Cellular componentpostsynaptic membrane
GO_0008076Cellular componentvoltage-gated potassium channel complex
GO_0032590Cellular componentdendrite membrane
GO_0005249Molecular functionvoltage-gated potassium channel activity
GO_0005251Molecular functiondelayed rectifier potassium channel activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKCNC3
Protein namePotassium voltage-gated channel subfamily C member 3
Potassium voltage-gated channel subfamily C member 3 (KSHIIID) (Voltage-gated potassium channel subunit Kv3.3)
Synonyms
DescriptionFUNCTION: Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics . It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells. Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis (By similarity). Required for normal motor function . Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex . .

AccessionsENST00000376959.6
ENST00000477616.2
ENST00000474951.1
A0A590UJ62
Q14003
E7ETH1
ENST00000670667.1
E9PQY4