KCNB2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006940Biological processregulation of smooth muscle contraction
GO_0051260Biological processprotein homooligomerization
GO_0006813Biological processpotassium ion transport
GO_0072659Biological processprotein localization to plasma membrane
GO_0001508Biological processaction potential
GO_0071805Biological processpotassium ion transmembrane transport
GO_0043204Cellular componentperikaryon
GO_0043025Cellular componentneuronal cell body
GO_0005886Cellular componentplasma membrane
GO_0008076Cellular componentvoltage-gated potassium channel complex
GO_0032809Cellular componentneuronal cell body membrane
GO_0016020Cellular componentmembrane
GO_0030425Cellular componentdendrite
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005251Molecular functiondelayed rectifier potassium channel activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKCNB2
Protein namePotassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2)
Synonyms
DescriptionFUNCTION: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. .

AccessionsENST00000523207.2
Q92953