KATNAL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051013Biological processmicrotubule severing
GO_0007283Biological processspermatogenesis
GO_0031122Biological processcytoplasmic microtubule organization
GO_0005813Cellular componentcentrosome
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0008352Cellular componentkatanin complex
GO_0005874Cellular componentmicrotubule
GO_0000922Cellular componentspindle pole
GO_0005819Cellular componentspindle
GO_0005737Cellular componentcytoplasm
GO_0008017Molecular functionmicrotubule binding
GO_0016853Molecular functionisomerase activity
GO_0008568Molecular functionmicrotubule severing ATPase activity
GO_0005515Molecular functionprotein binding
GO_0042802Molecular functionidentical protein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameKATNAL1
Protein nameKatanin catalytic subunit A1 like 1
Multifunctional fusion protein [Includes: Katanin p60 ATPase-containing subunit A1 (Katanin p60 subunit A1) (EC 5.6.1.1) (p60 katanin); Katanin p60 ATPase-containing subunit A-like 1 (Katanin p60 subunit A-like 1) (p60 katanin-like 1)]
Katanin p60 ATPase-containing subunit A-like 1 (Katanin p60 subunit A-like 1) (EC 5.6.1.1) (p60 katanin-like 1)
SynonymsKATNA1
DescriptionFUNCTION: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. .; FUNCTION: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays. .

FUNCTION: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule-severing activity in vitro . .

AccessionsA2A3H2
Q9BW62
ENST00000414289.5
Q5T558
ENST00000441394.1
ENST00000380617.7
B2RDY3
ENST00000380615.8