JAML report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046629Biological processgamma-delta T cell activation
GO_0030593Biological processneutrophil chemotaxis
GO_0060054Biological processpositive regulation of epithelial cell proliferation involved in wound healing
GO_0072672Biological processneutrophil extravasation
GO_0007157Biological processheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0035696Biological processmonocyte extravasation
GO_0005654Cellular componentnucleoplasm
GO_0005886Cellular componentplasma membrane
GO_0005923Cellular componentbicellular tight junction
GO_0050839Molecular functioncell adhesion molecule binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0005178Molecular functionintegrin binding

IV. Literature review

[source]
Gene nameJAML
Protein nameJunctional adhesion molecule-like (Adhesion molecule interacting with CXADR antigen 1) (Dendritic cell-specific protein CREA7-1)
AMICA1 protein
AMICA1 protein (cDNA FLJ58210, highly similar to Junctional adhesion molecule-like)
Junction adhesion molecule like
SynonymsUNQ722/PRO1387
AMICA1
DescriptionFUNCTION: Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR. .

AccessionsENST00000526620.5 [Q86YT9-4]
E9PNS8
E9PR26
E9PKK2
ENST00000525565.1
Q496M2
ENST00000533261.5
Q496M4
ENST00000292067.11 [Q86YT9-2]
Q496M3
E9PLF9
ENST00000526595.5
ENST00000356289.10 [Q86YT9-1]
ENST00000527877.5
Q86YT9
E9PJJ4
ENST00000524477.5