IZUMO1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IZUMO1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IZUMO1 at tissue level.

III. Associated gene sets

GO_0007338Biological processsingle fertilization
GO_0007155Biological processcell adhesion
GO_0035036Biological processsperm-egg recognition
GO_0007342Biological processfusion of sperm to egg plasma membrane involved in single fertilization
GO_0034113Biological processheterotypic cell-cell adhesion
GO_0002080Cellular componentacrosomal membrane
GO_0098635Cellular componentprotein complex involved in cell-cell adhesion
GO_0001669Cellular componentacrosomal vesicle
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0086080Molecular functionprotein binding involved in heterotypic cell-cell adhesion
GO_0042803Molecular functionprotein homodimerization activity
GO_0005102Molecular functionsignaling receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameIZUMO1
Protein nameIzumo sperm-oocyte fusion 1
Izumo sperm-egg fusion protein 1 (Oocyte binding/fusion factor) (OBF) (Sperm-specific protein izumo)
Synonyms
DescriptionFUNCTION: Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Acts a ligand for the human-specific oolemma epitope FCRL3/MAIA during fertilization . FCRL3/MAIA replaces IZUMO1R/JUNO as IZUMO1 receptor after sperm-egg adhesion, which permits species-specific gamete fusion . .

AccessionsENST00000595937.5 [Q8IYV9-2]
Q8IYV9
M0R0B8
ENST00000602105.1
ENST00000595517.5 [Q8IYV9-3]
ENST00000332955.7 [Q8IYV9-1]