Insufficient scRNA-seq data for expression of IZUMO1 at single-cell level.
Insufficient scRNA-seq data for expression of IZUMO1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 100% | 239.57 | 576 / 578 | 10% | 0.18 | 114 / 1155 |
adrenal gland | 95% | 43.98 | 246 / 258 | 14% | 0.47 | 32 / 230 |
pancreas | 100% | 229.90 | 328 / 328 | 4% | 0.07 | 7 / 178 |
spleen | 100% | 95.73 | 240 / 241 | 0% | 0 | 0 / 0 |
stomach | 85% | 209.47 | 304 / 359 | 8% | 0.16 | 22 / 286 |
breast | 90% | 37.63 | 413 / 459 | 2% | 0.02 | 17 / 1118 |
thymus | 89% | 28.00 | 582 / 653 | 1% | 0.03 | 7 / 605 |
kidney | 85% | 26.47 | 76 / 89 | 5% | 0.08 | 44 / 901 |
prostate | 85% | 24.51 | 208 / 245 | 5% | 0.11 | 23 / 502 |
adipose | 88% | 37.97 | 1058 / 1204 | 0% | 0 | 0 / 0 |
uterus | 75% | 16.82 | 128 / 170 | 8% | 0.15 | 36 / 459 |
esophagus | 63% | 15.98 | 909 / 1445 | 19% | 0.45 | 35 / 183 |
heart | 79% | 23.46 | 676 / 861 | 0% | 0 | 0 / 0 |
brain | 60% | 25.26 | 1598 / 2642 | 16% | 0.33 | 112 / 705 |
bladder | 67% | 13.00 | 14 / 21 | 6% | 0.12 | 30 / 504 |
intestine | 32% | 5.76 | 313 / 966 | 4% | 0.07 | 21 / 527 |
skin | 34% | 6.28 | 622 / 1809 | 0% | 0.01 | 1 / 472 |
muscle | 30% | 4.98 | 241 / 803 | 0% | 0 | 0 / 0 |
ovary | 26% | 4.24 | 47 / 180 | 2% | 0.03 | 7 / 430 |
liver | 21% | 5.19 | 47 / 226 | 3% | 0.05 | 12 / 406 |
blood vessel | 19% | 3.68 | 253 / 1335 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 7% | 0.09 | 3 / 45 |
peripheral blood | 2% | 0.28 | 20 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0007338 | Biological process | single fertilization |
GO_0007155 | Biological process | cell adhesion |
GO_0035036 | Biological process | sperm-egg recognition |
GO_0007342 | Biological process | fusion of sperm to egg plasma membrane involved in single fertilization |
GO_0034113 | Biological process | heterotypic cell-cell adhesion |
GO_0002080 | Cellular component | acrosomal membrane |
GO_0098635 | Cellular component | protein complex involved in cell-cell adhesion |
GO_0001669 | Cellular component | acrosomal vesicle |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0086080 | Molecular function | protein binding involved in heterotypic cell-cell adhesion |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0005102 | Molecular function | signaling receptor binding |
GO_0005515 | Molecular function | protein binding |
Gene name | IZUMO1 |
Protein name | Izumo sperm-oocyte fusion 1 Izumo sperm-egg fusion protein 1 (Oocyte binding/fusion factor) (OBF) (Sperm-specific protein izumo) |
Synonyms | |
Description | FUNCTION: Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Acts a ligand for the human-specific oolemma epitope FCRL3/MAIA during fertilization . FCRL3/MAIA replaces IZUMO1R/JUNO as IZUMO1 receptor after sperm-egg adhesion, which permits species-specific gamete fusion . . |
Accessions | ENST00000595937.5 [Q8IYV9-2] Q8IYV9 M0R0B8 ENST00000602105.1 ENST00000595517.5 [Q8IYV9-3] ENST00000332955.7 [Q8IYV9-1] |